Circulating CD31 + Angiogenic T cells are reduced in prediabetes and increase with exercise training.

Autor: Baker CJ; Greg Brown Diabetes & Endocrinology Research Laboratory, Charles Perkins Centre, University of Sydney, Sydney, Australia; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia., Min D; Greg Brown Diabetes & Endocrinology Research Laboratory, Charles Perkins Centre, University of Sydney, Sydney, Australia; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia., Marsh-Wakefield F; Liver Injury and Cancer Program, Centenary Institute, Sydney, NSW, Australia; Human Cancer and Viral Immunology Laboratory, The University of Sydney, Sydney, NSW, Australia., Siwan E; Greg Brown Diabetes & Endocrinology Research Laboratory, Charles Perkins Centre, University of Sydney, Sydney, Australia; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia., Gerofi J; Greg Brown Diabetes & Endocrinology Research Laboratory, Charles Perkins Centre, University of Sydney, Sydney, Australia; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia., Wang X; Greg Brown Diabetes & Endocrinology Research Laboratory, Charles Perkins Centre, University of Sydney, Sydney, Australia; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia., Hocking SL; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia; Boden Initiative, Charles Perkins Centre, University of Sydney, NSW, Australia., Colagiuri S; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; Boden Initiative, Charles Perkins Centre, University of Sydney, NSW, Australia., Johnson NA; Boden Initiative, Charles Perkins Centre, University of Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia., Twigg SM; Greg Brown Diabetes & Endocrinology Research Laboratory, Charles Perkins Centre, University of Sydney, Sydney, Australia; Central Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia. Electronic address: stephen.twigg@sydney.edu.au.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2024 Nov; Vol. 38 (11), pp. 108868. Date of Electronic Publication: 2024 Sep 17.
DOI: 10.1016/j.jdiacomp.2024.108868
Abstrakt: Aims: To investigate circulating angiogenic cells in adults with prediabetes and the effect of a structured exercise program.
Methods: A cohort of adults with overweight/obesity and either normal glucose (NG) or prediabetes were randomised to receive exercise (Exercise) (as twice weekly supervised combined high intensity aerobic exercise and progressive resistance training, and once weekly home-based aerobic exercise) or an unsupervised stretching intervention (Control) for 12 weeks. Circulating angiogenic T cells, muscle strength, and cardiovascular disease risk factors, including blood lipids, arterial stiffness, central haemodynamic responses, and cardiorespiratory fitness (VO 2 peak) in those with prediabetes (n = 35, 16 Control, 19 Exercise) and NG (n = 37, 17 Control, 20 Exercise) were analysed at baseline and after the 12-week intervention.
Results: At baseline, compared with NG those with prediabetes demonstrated reduced VO 2 peak, angiogenic CD31 + CD8 + T cells and VEGFR2 + CD4 + T cells, and increased systolic blood pressure. CD31 + T cells were negatively correlated with cardiovascular disease (CVD) risk. Compared with Control, exercise training increased muscle strength, VO 2 peak, and CD31 + CD4 + and CD31 + CD8 + T cells in NG and prediabetes.
Conclusions: Circulating angiogenic CD31 + T cells are decreased in people with prediabetes and are enhanced with exercise training. Exercise increases CD31 + T cells, and through this mechanism it is proposed that it may reduce CVD risk.
Trial Registration: Australian New Zealand Clinical Trials Registry number: ACTRN12617000552381.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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