A case of corticobasal syndrome possibly associated with anti-Yo antibodies.

Autor:	Angelopoulou E; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Constantinides VC; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Koumasopoulos E; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Stanitsa E; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Pyrgelis ES; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Kyrozis A; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Kapaki E; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Stefanis L; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece., Papageorgiou SG; 1st Department of Neurology, Aiginition University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Current medical research and opinion [Curr Med Res Opin] 2024 Oct; Vol. 40 (10), pp. 1737-1740. Date of Electronic Publication: 2024 Sep 25.
DOI:	10.1080/03007995.2024.2406888
Abstrakt:	Introduction: Corticobasal syndrome (CBS) is a rare form of atypical parkinsonism, most commonly caused by neurodegenerative disorders. Autoimmune underlying conditions are extremely rare, and anti-Yo antibody-associated CBS has not been reported yet. Case Report: Herein, we describe a case of a 68-year-old woman presenting with progressive dysarthria, gait instability and difficulty using her left hand with subacute deterioration during the last 3 months. Neurological examination revealed asymmetrical parkinsonism and pyramidal syndrome, reflex myoclonus and dystonia of her left upper limb, accompanied by apraxia of her left lower limb, fulfilling the criteria for possible CBS. Neuroimaging showed asymmetric frontoparietal atrophy, while cerebrospinal fluid and dopamine transporter imaging were normal. Prior to our evaluation, antineuronal autoantibody testing indicated positive anti-Yo antibodies. There was mild improvement after second IVIG cycle, and further investigation revealed no tumor. Conclusion: Although autoimmune etiology of this case cannot be certain, it highlights the potential expansion of the clinical spectrum of anti-Yo-associated paraneoplastic syndrome.
Databáze:	MEDLINE
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