p-Terphenyl and Orsellinic Acid Derivatives from the European Polyporales Terana coerulea and Sparassis brevipes.

Autor: Chemutai Sum W; Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany Tel.; Institute of Microbiology, Faculty of Life Sciences, Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany., Ebada SS; Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany Tel.; Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, 11566, Cairo, Egypt., Kellner H; Department of Bio- and Environmental Sciences, Technische Universität Dresden-International Institute Zittau, Markt 23, 02763, Zittau, Germany., Stadler M; Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany Tel.; Institute of Microbiology, Faculty of Life Sciences, Institute of Microbiology, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep 19, pp. e202401597. Date of Electronic Publication: 2024 Sep 19.
DOI: 10.1002/cbdv.202401597
Abstrakt: Investigation of the secondary metabolites of the solid-state rice cultures from the European basidiomycetes Terana coerulea and Sparassis brevipes afforded three previously undescribed secondary metabolites identified as two p-terphenyl derivatives (1 and 2) and one orsellinic acid congener (3) in addition to another known, isoeverninic acid (4). Chemical structures of the isolated compounds were elucidated through comprehensive 1D and 2D NMR spectroscopic analyses, coupled with HR-MS and other spectral methods. The isolated compounds were assessed for their cytotoxic and antimicrobial activities. Compound 1 revealed weak antimicrobial properties, whereas the inseparable mixture of 3 and 4 featured moderate cytotoxic and antimicrobial effects.
(© 2024 The Author(s). Chemistry & Biodiversity published by Wiley-VHCA AG.)
Databáze: MEDLINE
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