FeBr 3 -catalysed synthesis of 3-aroylimidazo[1,2- a ]pyridine and 3,3'-(arylmethylene)bis(2-phenylimidazo[1,2- a ]pyridines) derivatives from 2-arylimidazo[1,2- a ]pyridines and aromatic aldehydes: an investigation about mechanistic insights.

Autor: Hung TQ; Institute of Chemistry, Vietnam Academy of Science and Technology Vietnam tqhung@ich.vast.vn.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology Vietnam., Phuc BV; Institute of Chemistry, Vietnam Academy of Science and Technology Vietnam tqhung@ich.vast.vn., Nguyen MP; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU) Vietnam dangthanhtuan@hus.edu.vn., Tran TL; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU) Vietnam dangthanhtuan@hus.edu.vn., Do DV; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU) Vietnam dangthanhtuan@hus.edu.vn., Nguyen HT; Institute of Chemistry, Vietnam Academy of Science and Technology Vietnam tqhung@ich.vast.vn.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology Vietnam., Nguyen VT; Institute of Chemistry, Vietnam Academy of Science and Technology Vietnam tqhung@ich.vast.vn.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology Vietnam., Nguyen H; Faculty of Chemistry, Hanoi National University of Education (HNUE) Vietnam., Dang TT; Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU) Vietnam dangthanhtuan@hus.edu.vn.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2024 Sep 18; Vol. 14 (40), pp. 29535-29541. Date of Electronic Publication: 2024 Sep 18 (Print Publication: 2024).
DOI: 10.1039/d4ra05198j
Abstrakt: In a new approach, a series of 3-aroylimidazo[1,2- a ]pyridine derivatives were prepared in high yields. This approach revealed the direct Fe-catalyzed functionalization of imidazo[1,2- a ]pyridine derivatives with aryl aldehydes via an aerobic oxidative cross-dehydrogenative coupling process. This transformation occurred in the presence of air, and FeBr 3 served as a homogeneous Lewis catalyst. O 2 was found to be the principal oxidant responsible for the method's success. Interestingly, when these reactions were carried out under an argon atmosphere, 3,3'-(arylmethylene)bis(2-phenylimidazo[1,2- a ]pyridines) derivatives were prepared in good yields.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
Externí odkaz: