Recent Updates on the Management of Split-thickness Skin Graft Donor Sites.
| Autor: | Markel JE; From the Department of Internal Medicine, Cedars-Sinai Medical Center, West Hollywood, Calif., Franke JD; Department of Plastic and Reconstructive Surgery, Corewell Health-Michigan State University College of Human Medicine, Grand Rapids, Mich., Woodberry KM; Department of Plastic, Reconstructive, and Hand Surgery, West Virginia University, Grand Rapids, Mich., Fahrenkopf MP; Department of Plastic and Reconstructive Surgery, Elite Plastic Surgery, Grand Rapids, Michigan. |
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| Jazyk: | angličtina |
| Zdroj: | Plastic and reconstructive surgery. Global open [Plast Reconstr Surg Glob Open] 2024 Sep 18; Vol. 12 (9), pp. e6174. Date of Electronic Publication: 2024 Sep 18 (Print Publication: 2024). |
| DOI: | 10.1097/GOX.0000000000006174 |
| Abstrakt: | Background: This article is a narrative review of split-thickness skin graft donor site (STSG-DS) management since the international guidelines were created in 2018. Although many new interventions have been developed, there is a lack of quality, multicentered clinical trials to produce updated evidence-based recommendations. Methods: Electronic databases, including Google Scholar, Web of Science, Medline, and PubMed, were searched by two independent researchers for literature regarding STSG-DS management published from 2018 through 2022, using specific terms in the text, title, and abstract. The primary endpoint assessed was STSG-DS healing, as measured by wound epithelialization. Results: Thirty-one articles were selected, including three systemic review/meta-analyses, five case series, 14 randomized controlled clinical trials, six observational studies, and three nonrandomized trials. Novel interventions for STSG-DS management included in this article describe applications of human amniotic membranes, acellular dermal matrices, cell suspensions and growth factors, biomaterials, electromagnetic radiation, and natural products. Conclusion: Various interventions have shown promise for STSG-DS management since the creation of the 2018 international guidelines; however, studies with more standardized protocols and endpoints are needed to produce up-to-date, evidence-based recommendations and improve outcomes for patients undergoing split-thickness skin grafting. Competing Interests: The authors have no financial interest to declare in relation to the content of this article. (Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.) |
| Databáze: | MEDLINE |
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