Biochemical assessment in a cohort of pediatric patients with cystic fibrosis.

Autor: Anghel Delia CE; Faculty of Biology, University of Bucharest, Bucharest, Romania.; Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania., Negrescu AM; Faculty of Biology, University of Bucharest, Bucharest, Romania., Stan IV; Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania.; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Iacoban SR; Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania.; Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Moiceanu ES; Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Cluj-Napoca, Romania.; Emergency Clinical Hospital for Children 'Grigore Alexandrescu'., Toma GM; Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania., Ionica E; Faculty of Biology, University of Bucharest, Bucharest, Romania., Cimpean A; Faculty of Biology, University of Bucharest, Bucharest, Romania.
Jazyk: angličtina
Zdroj: Journal of medicine and life [J Med Life] 2024 Jun; Vol. 17 (6), pp. 610-619.
DOI: 10.25122/jml-2024-0288
Abstrakt: Cystic fibrosis (CF) is a recessive inherited disorder caused by genetic mutations in the CF transmembrane conductance regulator ( CFTR ) gene. It is a multisystem condition that primarily induces abnormal mucus accumulation in the respiratory system and obstructs the intrapancreatic common bile duct, causing a reduction in the delivery of digestive enzymes to the small intestine. Thus, patients with CF are characterized by maldigestion, malabsorption, and recurrent airway bacterial infections. Clinical monitoring of the health status of patients with CF is mandatory for increasing the patients' lifespan. To assess the feasibility of monitoring life quality (LQ) in pediatric patients with cystic fibrosis (CF) and to explore the relationship between biochemical parameters and clinical symptoms, our study analyzed inflammatory responses related to CF, medication, and pulmonary bacterial infections in 52 patients diagnosed with CF. Blood, hypo-pharyngeal exudate, and fecal samples were analyzed using clinical biochemistry, hematology, and microbiology techniques at the Alessandrescu-Rusescu National Institute for Mother and Child Health central laboratory in Bucharest, Romania. All the participants adhered to their prescribed outpatient CF regimens and appeared clinically stable. The overall clinical status of patients with CF was observed and compared with that of a healthy control group, which consisted of individuals similar in number and age. The screened patients with CF presented an impaired lipid status and chronic infections with various bacteria, iron, and vitamin (A, D, and E) deficiencies. Our findings provide insights into the pathophysiological mechanisms of CF and suggest that tailored monitoring and personalized therapeutic strategies could improve patient management.
Competing Interests: The authors declare no conflict of interest.
(© 2024 by the authors.)
Databáze: MEDLINE
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