Scarring Alopecia in Tumor Necrosis Factor-α Antagonists-Induced Scalp Psoriasis.

Autor:	Baniel A; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel.; Sackler Faculty of Medicine, TelAviv University, Israel., Peled A; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel., Samuelov L; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel.; Sackler Faculty of Medicine, TelAviv University, Israel., Zemser V; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel., Gat A; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel., Dodiuk-Gad RP; Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Israel.; Department of Dermatology, Emek Medical Center, Israel.; Department of Medicine, University of Toronto, ON, Canada., Ziv M; Department of Dermatology, Emek Medical Center, Israel., Azzam W; Department of Dermatology, Emek Medical Center, Israel., Zittan E; Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Israel.; The Abraham and Sonia Rochlin IBD Unit, Department of Gastroenterology, Emek Medical Center, Israel., Matz H; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel., Sprecher E; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel.; Sackler Faculty of Medicine, TelAviv University, Israel., Pavlovsky M; Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel.
Jazyk:	angličtina
Zdroj:	Journal of psoriasis and psoriatic arthritis [J Psoriasis Psoriatic Arthritis] 2023 Jul; Vol. 8 (3), pp. 90-95. Date of Electronic Publication: 2023 Apr 26.
DOI:	10.1177/24755303231173376
Abstrakt:	Background: A broad spectrum of adverse reactions associated with the use of tumor necrosis factor alpha (TNFα) antagonists has been recognized over the past years. Induction of scalp psoriasis is a less known undesirable consequence of the use of these drugs and is not well characterized. Objective: To characterize TNFα inhibitors-induced psoriatic alopecia. Methods: We studied 6 patients with TNF-inhibitor induced psoriatic alopecia and reviewed 28 patients with this condition reported in the literature to date. Results: In addition to severe scalp psoriasis, we report hair follicle pathologies ranging from alopecia areata to scarring alopecia. Prognosis was good, but discontinuation of TNFα inhibitors was required in more than half of the cases in order to achieve a favourable outcome. Conclusion: TNFα inhibitors-associated psoriatic alopecia is rarely reported but requires a high index of suspicion and prompt diagnosis, as timely intervention may prevent irreversible damage. Competing Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: RDG has received research support and consulting fees from Janssen, Abbvie, Sanofi, Novartis, Pfizer; EZ has received research support and consulting fees from Janssen, Abbvie, Takeda, Neopharm, Celgene and Pfizer; MP has received research support from Pfizer. (© The Author(s) 2023.)
Databáze:	MEDLINE
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