Prevalence and Prognostic Impact of Hyponatremia in Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis.

Autor:	Ekmekyapar Fırat Y; Neurology, Sanko University School of Medicine, Gaziantep, TUR., Karaoglu Akıncı Z; Neurology, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, TUR., Belen BG; Neurology, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, TUR., Türkok CG; Neurology, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, TUR., Sahin S; Neurology, University of Health Sciences, Sancaktepe Research and Training Hospital, Istanbul, TUR., Karsidag S; Neurology, Sultan 2. Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 19; Vol. 16 (8), pp. e67215. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).
DOI:	10.7759/cureus.67215
Abstrakt:	This study aims to systematically review the existing literature and perform a meta-analysis to evaluate the prevalence of hyponatremia among Guillain Barre Syndrome (GBS) patients and its relationship with disease prognosis. We comprehensively searched PubMed, Embase, Medline, Web of Science, Science Direct, and the Cochrane Library databases from 1995 to 2024 for observational studies on the prevalence of hyponatremia in GBS. The meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. Heterogeneity among the included studies was calculated with the I 2 for each analysis. We used the Comprehensive Meta-Analysis software (Version 3.3.070; Biostat, Englewood, USA). Eight observational studies met our inclusion criteria. The meta-analysis showed that the pooled prevalence of hyponatremia among GBS patients was 12% (95% CI: 0.107-0.149). The results exhibited high heterogeneity (I² = 99%), indicating significant variability among the studies. Hyponatremia rates reported in these eight studies ranged from 11.5% to 48% in GBS patients. The prevalence of hyponatremia was found to be 12% in GBS patients, which is relatively lower compared to some reports. Hyponatremia was found to be associated with prolonged hospital stay, mortality, and mechanical ventilation as poor prognostic factors. Further prospective studies are needed to elucidate the mechanisms underlying hyponatremia in GBS and to develop targeted interventions to address this issue. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Ekmekyapar Fırat et al.)
Databáze:	MEDLINE
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