Harnessing PROTACs to combat H5N1 influenza: A new frontier in viral destruction.

Autor: Mukerjee N; Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Chennai, India., Maitra S; Department of Microbiology, Adamas University, Kolkata, India., Mukherjee D; Department of Medicine, Raiganj Govt Medical College and Hospital, Uttar Dinajpur, India., Ghosh A; Department of Molecular Biology and Bioinformatics, Tripura University (A Central University), Suryamaninagar, India., Alexiou AT; Department of Science and Engineering, Novel Global Community Educational Foundation, Sydney, New South Wales, Australia., Thorat ND; Department of Physics, Bernal Institute and Limerick Digital Cancer Research Centre (LDCRC), University of Limerick, Castletroy, Ireland.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2024 Sep; Vol. 96 (9), pp. e29926.
DOI: 10.1002/jmv.29926
Abstrakt: H5N1, a highly pathogenic avian influenza virus, poses an ongoing and significant threat to global public health, primarily due to its potential to cause severe respiratory illness and high mortality rates in humans. Despite extensive efforts in vaccination and antiviral therapy, H5N1 continues to exhibit high mutation rates, resulting in recurrent outbreaks and the emergence of drug-resistant strains. Traditional antiviral therapies, such as neuraminidase inhibitors and M2 ion channel blockers, have demonstrated limited efficacy, necessitating the exploration of innovative therapeutic strategies. Proteolysis-targeting chimeras (PROTACs) emerge as a novel and promising approach, leveraging the ubiquitin-proteasome system to selectively degrade pathogenic proteins. Unlike conventional inhibitors that only block protein function, PROTACs eliminate the target protein, providing a sustained therapeutic effect and potentially reducing the development of resistance. This paper offers a comprehensive examination of the current landscape of H5N1 infections, detailing the pathogenesis and challenges associated with existing treatments. It further explores the mechanism of action, design, and therapeutic potential of PROTACs in inhibiting H5N1. By targeting essential viral proteins, such as hemagglutinin and the RNA-dependent RNA polymerase complex, PROTACs hold the potential to revolutionize the treatment of H5N1 infections, offering a new frontier in antiviral therapy.
(© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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