Lipid redistribution due to a cell-cell fusion pore.
| Autor: | Allender DW; Department of Physics, University of Washington, Seattle, Washington; Department of Physics, Kent State University, Kent, Ohio., Schick M; Department of Physics, University of Washington, Seattle, Washington. Electronic address: schick@uw.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Biophysical journal [Biophys J] 2024 Oct 15; Vol. 123 (20), pp. 3640-3645. Date of Electronic Publication: 2024 Sep 18. |
| DOI: | 10.1016/j.bpj.2024.09.015 |
| Abstrakt: | We consider the redistribution of lipids comprising the plasma membranes during cell-cell fusion, particularly due to the presence of a fusion pore. Assuming the membranes are of constant thickness, we find that the mole fraction of cholesterol increases in the directly apposed exoplasmic leaflets, and is decreased in the cytoplasmic leaflets. The redistribution of the phospholipids is obtained as well. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Biophysical Society. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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