Assessment of verbal memory in Parkinson's disease utilizing a virtual reality-based Rey Auditory Verbal Learning Test.

Autor: Gottlieb A; Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel. amihai.gottlieb@gmail.com., Kimel-Naor S; Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Zeilig G; Department of Neurological Rehabilitation, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; School of Health Professions, Ono Academic College, Kiryat Ono, Israel., Schnaider Beeri M; The Hebert and Jacqueline Krieger Klein Alzheimer's Research Center, Brain Health Institute, Rutgers Health, Newark, NJ, USA., Plotnik M; Center of Advanced Technologies in Rehabilitation, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.; Department of Physiology and Pharmacology, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 18; Vol. 14 (1), pp. 21792. Date of Electronic Publication: 2024 Sep 18.
DOI: 10.1038/s41598-024-71618-6
Abstrakt: The Rey Auditory Verbal Learning Test (RAVLT) is a commonly used tool for evaluating verbal learning and memory in neuropsychological assessments. In recent years, we developed a Virtual Reality (VR) adaptation of the RAVLT (VR-RVLT), aiming for increased ecological validity compared to the traditional pen and paper gold standard (GS-RAVLT). Following validation in healthy cohorts, the VR-RAVLT was validated with thirty individuals with Parkinson's Disease (PD) that completed both the GS-RAVLT and the VR- RAVLT. Validity of the VR-RAVLT was evaluated by assessing its construct and discriminant validity, and test-retest reliability, in comparison to the GS-RAVLT. Results of the PD participants were compared to those of 46 previously recruited healthy participants with comparable age and level of education. Main outcome measures derived from the remembered items on the test lists, exhibited significant and comparable correlations between VR-RAVLT and GS-RAVLT, both among healthy participants and PD participants. Likewise, serial position effects were similar for both formats amog the PD participants. Additionally, both formats showed similar discriminatory ability between healthy controls and PD participants, as well as comparable test-retest reliability measures. Taken together, the results suggest that the VR-based RAVLT is equally effective in measuring verbal memory capabilities in individuals with PD as compared to the GS-RAVLT. Certain results indicate that the virtual reality version has the capability to encompass additional factors that might impact memory performance, thereby suggesting an enhanced ecological validity.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje