Challenges and complications in juvenile localized scleroderma: A practical approach.

Autor: Pain CE; Department of Rheumatology, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, UK; Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK. Electronic address: clare.pain@alderhey.nhs.uk., Torok KS; Division of Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, University of Pittsburgh Scleroderma Center, 4401 Penn Ave Pittsburgh, Pennsylvania, USA, 15224. Electronic address: kathryn.torok@chp.edu.
Jazyk: angličtina
Zdroj: Best practice & research. Clinical rheumatology [Best Pract Res Clin Rheumatol] 2024 Sep; Vol. 38 (3), pp. 101987. Date of Electronic Publication: 2024 Sep 17.
DOI: 10.1016/j.berh.2024.101987
Abstrakt: Juvenile localized scleroderma is characterised by inflammation which drives fibrosis in skin and soft tissues. The more severe subtypes of localized scleroderma such as linear and craniofacial are more common in children. Additionally, extracutaneous involvement is seen in half of all children and is associated with poorer treatment outcomes and health-related quality of life. Evidence for the management of craniofacial and extracutaneous involvement is lacking and therefore poses a challenge to clinicians. This review aims to provide a practical approach to management of these most challenging features of juvenile localized scleroderma through case studies where we present the available evidence, current recommendations and considerations for management.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: