A cellular identity crisis? Plasticity changes during aging and rejuvenation.

Autor:	Gorelov R; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Hochedlinger K; Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; khochedlinger@helix.mgh.harvard.edu.; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jazyk:	angličtina
Zdroj:	Genes & development [Genes Dev] 2024 Oct 16; Vol. 38 (17-20), pp. 823-842. Date of Electronic Publication: 2024 Oct 16.
DOI:	10.1101/gad.351728.124
Abstrakt:	Cellular plasticity in adult multicellular organisms is a protective mechanism that allows certain tissues to regenerate in response to injury. Considering that aging involves exposure to repeated injuries over a lifetime, it is conceivable that cell identity itself is more malleable-and potentially erroneous-with age. In this review, we summarize and critically discuss the available evidence that cells undergo age-related shifts in identity, with an emphasis on those that contribute to age-associated pathologies, including neurodegeneration and cancer. Specifically, we focus on reported instances of programs associated with dedifferentiation, biased differentiation, acquisition of features from alternative lineages, and entry into a preneoplastic state. As some of the most promising approaches to rejuvenate cells reportedly also elicit transient changes to cell identity, we further discuss whether cell state change and rejuvenation can be uncoupled to yield more tractable therapeutic strategies. (© 2024 Gorelov and Hochedlinger; Published by Cold Spring Harbor Laboratory Press.)
Databáze:	MEDLINE
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