The Circulating CDC42 Expression in Sepsis: Relation to Disease Susceptibility, Inflammation, Multiple Organ Dysfunctions and Mortality Risk.

Autor: Chen M; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., Gao K; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., Guo Z; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., Feng L; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., Feng Y; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., Fu J; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., Li H; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China., An J; Department of Intensive Care Unit, Affiliated Hospital of Hebei University of Engineering, Handan, China jingying4917303702@163.com.
Jazyk: angličtina
Zdroj: Annals of clinical and laboratory science [Ann Clin Lab Sci] 2024 Jul; Vol. 54 (4), pp. 525-532.
Abstrakt: Objective: Cell division cycle 42 (CDC42) modulates inflammation and multiple organ dysfunction by regulating T-cell differentiation and macrophage polarization. This research intended to explore the association of blood CDC42 expression with septic risk, multi-organ dysfunctions, and mortality.
Methods: 145 sepsis patients and 50 health controls were recruited, then CDC42 expression in peripheral blood mononuclear cell (PBMC) from them was measured by RT-qPCR.
Results: CDC42 was decreased in sepsis patients versus health controls ( P <0.001); meanwhile, the receiver operating characteristic (ROC) curve showed that CDC42 had a certain value to predict sepsis risk with an area under the curve (AUC) (95% confidence interval (CI): 0.797 (0.725-0.869). Furthermore, CDC42 was negatively correlated with C-reactive protein ( P <0.001), tumor necrosis factor-alpha ( P <0.001) and interleukin-17A ( P <0.001) but less with interleukin-6 ( P =0.056). Moreover, CDC42 was negatively related to the SOFA score ( P <0.001) and its several subscales (respiratory system, liver, cardiovascular, and renal system) ( P <0.05). Furthermore, CDC42 was lower in septic deaths versus survivors ( P <0.001); meanwhile, the ROC curve exhibited a certain ability of CDC42 in estimating 28-day mortality with an AUC (95%CI) of 0.766 (0.676-0.855).
Conclusion: Circulating CDC42 exhibits potency to be a prognostic biomarker reflecting multi-organ dysfunctions and higher mortality risk in sepsis.
(© 2024 by the Association of Clinical Scientists, Inc.)
Databáze: MEDLINE