Differential effects of social versus monetary incentives on inhibitory control under acute inflammation.

Autor: Alvarez GM; Department of Psychology, University of Pittsburgh, Pittsburgh, PA USA; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA. Electronic address: gabyalvarez@pitt.edu., Jolink TA; Department of Psychology, University of Michigan, Ann Arbor, MI USA; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., West TN; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., Cardenas MN; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., Feldman MJ; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., Cohen JR; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA., Muscatell KA; Department of Psychology & Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC USA; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1016/j.bbi.2024.09.010
Abstrakt: While the impact of chronic, low-grade inflammation on cognitive functioning is documented in the context of neurodegenerative disease, less is known about the association between acute increases in inflammation and cognitive functioning in daily life. This study investigated how changes in interleukin-6 (IL-6) levels were associated with performance on an inhibitory control task, the go/no-go task. We further examined whether the opportunity to earn different incentive types (social or monetary) and magnitudes (high or low) was associated with differential performance on the task, depending on IL-6 levels. Using a within-participant design, individuals completed an incentivized go/no-go task before and after receiving the annual influenza vaccine. Multilevel logistic regressions were performed on the trial-level data (N obs  = 30,528). For no-go trials, we did not find significant associations between IL and 6 reactivity between the sessions and changes in trial accuracy. For go trials, we found significant differences in the associations between IL and 6 reactivity and changes in accuracy from session 1 to session 2 as a function of the incentive condition. Notably, greater IL-6 reactivity was consistently associated with fewer omission errors (i.e., greater accuracy on go trials) on high-magnitude social incentives (i.e., viewing a picture of a close-other picture) when compared to both low-magnitude social and high-magnitude monetary incentives. Together, these results suggest that mild fluctuations in inflammation might alter the valuation of an incentive, and possibly a shift toward devoting greater attentional resources when a large social incentive is on the line. Overall, this study sheds light on how everyday, low-grade fluctuations in inflammation may influence cognitive abilities essential for daily life and effective inhibitory control.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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