The association between perinatal depressive symptoms and child neurodevelopment.

Autor: Miller ES; Departments of Obstetrics and Gynecology of Northwestern University, Chicago, IL (Miller). Electronic address: EmMiller@wihri.org., Costantine MM; The Ohio State University, Columbus, OH (Costantine)., Mele L; George Washington University Biostatistics Center, Washington, DC (Mele)., Varner MW; University of Utah Health Sciences Center, Salt Lake City, UT (Varner)., Reddy UM; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD (Reddy)., Wapner RJ; Columbia University, New York, NY (Wapner)., Thorp JM Jr; University of North Carolina, Chapel Hill, NC (Thorp)., Saade GR; University of Texas Medical Branch, Galveston, TX (Saade)., Tita ATN; University of Alabama at Birmingham, Birmingham, AL (Tita)., Rouse DJ; Brown University, Providence, RI (Rouse)., Sibai B; University of Texas-Houston, Houston, TX (Sibai)., Mercer BM; Case Western Reserve University, Cleveland, OH (Mercer)., Caritis SN; University of Pittsburgh, Pittsburgh, PA (Caritis)., Casey BM; University of Texas-Southwestern, Dallas, TX (Casey).
Jazyk: angličtina
Zdroj: American journal of obstetrics & gynecology MFM [Am J Obstet Gynecol MFM] 2024 Nov; Vol. 6 (11), pp. 101488. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1016/j.ajogmf.2024.101488
Abstrakt: Background: Perinatal depression has been suggested to adversely impact child neurodevelopment. However, the complexity of the early childhood environment challenges conclusive findings.
Objective: To evaluate whether there is an association between perinatal depressive symptoms and child intelligence quotient (IQ) at 5 years of age.
Study Design: Secondary analysis of an ancillary study to a multicenter randomized trial of thyroxine therapy for pregnant individuals with subclinical hypothyroidism. Dyads of infants and birthing parent, with completed Center for Epidemiological Studies-Depression (CES-D) screens during pregnancy and postpartum and child neurodevelopment testing completed at five years of age (n=209) were included. CES-D screening was performed at 11-20 weeks, 34-38 weeks, and one-year postpartum. Depressive symptoms were categorized as antenatal (i.e., a positive screen at any point during pregnancy) or postpartum. The primary outcome was child IQ score < 85 at 5 years of age using the Wechsler Preschool and Primary Scale of Intelligence III (WPPSI-III) Full Scale test. Secondary outcomes included other assessments of childhood neurodevelopment. Bivariable analyses and multivariable logistic regressions were utilized.
Results: Of the 209 birthing people included, 72 (34%) screened positive for depression during pregnancy and 32 (15%) screened positive one year postpartum. Children born to individuals with a positive antenatal depression screen had a higher odds of IQ < 85 at 5 years of age compared with children born to individuals with a CES-D < 16 (35% vs. 18%, OR 2.4, 95% CI 1.2-4.7). Similar findings were seen for children born to individuals with a positive postpartum depression screen (47% vs. 21%, OR 3.3, 95% CI 1.5-7.3). These associations did not persist in multivariable analyses that controlled for social determinants of health and clinical characteristics (adjusted odd ratio [aOR] 1.4, 95% CI 0.7-3.1; aOR 2.1, 95% CI 0.9-5.1, for antenatal and postpartum depressive symptoms, respectively). Similar findings were observed for other adverse neurodevelopmental outcomes.
Conclusions: Having a positive perinatal depression screen was not associated with child cognitive outcomes after controlling for covariates including social determinants of health.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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