Singlet Oxygen-Triggered Release of Nitric Oxide in an Endoperoxide-Arginine Conjugate.

Autor: Zhang G; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China., Wang L; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China., Qiao Y; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China., Sun R; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China., Liu Z; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China., Akkaya EU; State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.
Jazyk: angličtina
Zdroj: Chemistry, an Asian journal [Chem Asian J] 2024 Dec 16; Vol. 19 (24), pp. e202400759. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1002/asia.202400759
Abstrakt: Nitric oxide (NO) is an important signaling molecule in both healthy and pathological processes. In this work, we present the first example of a novel class of organic NO-donor compounds with minimal toxicity. The release is driven by the reaction of singlet oxygen spontaneously produced by the cycloreversion reaction of the endoperoxide. Cell culture and imaging data confirms the release of NO in this bimodular system.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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