The effect of aging on mast cell density in human skin: a comparative analysis of photoexposed and photoprotected regions.

Autor:	Lestarevic S; Department of Histology and Embryology, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia. slestarevic@yahoo.com., Savic S; Department of Histology and Embryology, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia., Dejanovic M; Department of Physiology, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia., Mijovic M; Department of Pathology, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia., Mandic P; Department of Anatomy, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia., Marjanovic D; Department of Dentistry, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia., Filipovic M; Department of Surgery, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia., Rancic IB; Department of Histology and Embryology, Faculty of Medicine in Nis, Nis, Serbia., Jorgacevic T; Department of Histology and Embryology, Faculty of Medicine in Pristina-Kosovska Mitrovica, Kosovska Mitrovica, Serbia.
Jazyk:	angličtina
Zdroj:	Folia morphologica [Folia Morphol (Warsz)] 2024 Sep 18. Date of Electronic Publication: 2024 Sep 18.
DOI:	10.5603/fm.102163
Abstrakt:	Background: Mast cells are mononuclear cells originating from bone marrow. They produce various biologically active substances, which allow them to actively participate in immune and inflammatory processes associated with intrinsic and extrinsic skin aging. This research focused on distribution and density of mast cells in healthy skin in different stages of skin aging. Material and Methods: This project included samples of photoexposed and photoprotected skin, obtained from 90 cadavers aged 0-82 years. The samples were classified into five age groups: newborns, young age, middle age, senior age and the oldest age. In order to visualize the mast cells, we have employed several histochemical staining protocols. Results: The number of mast cells of the photoexposed skin significantly correlated to the individual's age. The number of mast cells of the photoprotected skin was in general statistically significantly lower in younger compared to older groups; however, the correlation of the mast cell density in photoprotected skin and the age did not reach statistical significance. In middle age, senior age and the oldest age groups, a significantly higher number of mast cells was recorded in the skin of the photoexposed compared to photoprotected region. Conclusions: The increase in mast cell density correlated with age only in photoexposed skin. Age-related higher accumulation of dermal mast cells in photoexposed skin can be an important factor in the photoaging process, as well as the contributing factor in the occurrence of skin cancer.
Databáze:	MEDLINE
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