ABO Discrepancy in a Patient With Plasma Cell Myeloma.

Autor:	Adzahar S; Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Daud A; Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Razak SMA; Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Abdul Jalil K; Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Nordin MH; Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Mohamad Mustafa M'N; Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Mohd Shukri DH; Department of Pathology and Medical Laboratory, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Azhar A; Department of Pathology and Medical Laboratory, Faculty of Medicine, Hospital Universiti Sultan Zainal Abidin, Kuala Terengganu, MYS., Syed Abdul Rahman SS; Department of Pathology and Medical Laboratory, Hospital Universiti Sultan Zainal Abidin, Terengganu, MYS., Zulkeflee RH; Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 17; Vol. 16 (8), pp. e67096. Date of Electronic Publication: 2024 Aug 17 (Print Publication: 2024).
DOI:	10.7759/cureus.67096
Abstrakt:	ABO discrepancies in plasma cell myeloma (PCM) present unique challenges in blood typing tests and transfusion management. We present the case of a 51-year-old male with PCM who exhibited discrepancies between forward and reverse blood grouping. Further investigation revealed that the patient's blood type was a variant of blood group B. While type III discrepancies, typically characterized by elevated globulin levels causing false-positive reactions in both forward and reverse blood grouping, are common in multiple myeloma, our case differed due to the loss of B antigens secondary to the malignant condition. This caused a discrepancy in forward blood grouping. The rarity of ABO discrepancies in multiple myeloma underscores the importance of thorough evaluation. Awareness of potential antigen alterations in such patients is crucial to ensure safe transfusion practices. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Adzahar et al.)
Databáze:	MEDLINE
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