Tools for Screening, Predicting, and Evaluating Sepsis and Septic Shock: A Comprehensive Review.
| Autor: | Aggrawal K; Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, IND., Verma S; Internal Medicine, Government Medical College, Amritsar, Amritsar, IND., Stoltzfus MT; Neurosurgery, Penn State College of Medicine, Hershey, USA., Singh B; Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, Queens, USA., Anamika F; Medical School, University College of Medical Sciences, New Delhi, IND., Jain R; Internal Medicine, Penn State Health Milton S. Hershey Medical Center, Hershey, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Aug 18; Vol. 16 (8), pp. e67137. Date of Electronic Publication: 2024 Aug 18 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.67137 |
| Abstrakt: | Sepsis is characterized by life-threatening organ dysfunction due to dysregulated host response to infection. It can progress to cause circulatory and cellular/metabolic abnormalities, resulting in septic shock that may significantly increase mortality. The pathophysiology of sepsis involves a complex interplay of invading pathogens and the body's immune defense, causing alteration in normal homeostasis, eventually leading to derangements in the cellular, humoral, circulatory, and metabolic functions. Several scoring systems have been developed to rapidly predict or suspect sepsis, such as Sequential Organ Failure Assessment (SOFA), modified SOFA (mSOFA), quick SOFA (qSOFA), shock index (SI), and modified SI (mSI). Each of these scores has been utilized for triaging patients with sepsis, and as per medical advancements these scoring systems have been modified to include or exclude certain criteria to improve their clinical utility. This review aims to compare the individual scores and their usage for sepsis that may be used for laying the foundation for early recognition and prediction of sepsis and for formulating more precise definitions in the future. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Aggrawal et al.) |
| Databáze: | MEDLINE |
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