Evaluation of the influenza-like illness case definition and the acute respiratory infection case definition in the diagnosis of influenza and COVID-19 in healthcare personnel.

Autor: Maltezou HC; Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece. Electronic address: maltezou.helena@gmail.com., Sourri F; 251 Hellenic Air Force General Hospital, Athens, Greece., Lemonakis N; Infection Control Committee, University Hospital of Alexandroupolis, Alexandroupolis, Greece., Karapanou A; Infection Control Committee, Laiko General Hospital, Athens, Greece., Giannouchos TV; Department of Health Policy & Organization, School of Public Health, The University of Alabama at Birmingham, Birmingham, AL, United States., Gamaletsou MN; Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Greece., Koukou DM; First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece., Souliotis K; Faculty of Social and Political Sciences, University of Peloponnese, Corinth, Greece; Health Policy Institute, Athens, Greece., Lourida A; Infection Control Committee, Aghia Sofia Children's Hospital, Athens, Greece., Panagopoulos P; Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece., Hatzigeorgiou D; Medical Directorate, Hellenic National Defence General Staff, Athens, Greece., Sipsas NV; Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Greece.
Jazyk: angličtina
Zdroj: Infection, disease & health [Infect Dis Health] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1016/j.idh.2024.08.002
Abstrakt: Background: To evaluate the influenza-like illness (ILI) and acute respiratory infection (ARI) case definitions in the diagnosis of COVID-19 and influenza in healthcare personnel (HCP).
Methods: We followed a cohort of 5752 HCP from November 2022 to May 2023. Symptomatic HCP were tested for SARS-CoV-2 and influenza by real-time PCR and/or rapid antigen detection test. ILI was defined as the sudden onset of ≥1 systemic symptom and ≥1 respiratory symptom. ARI was defined as the sudden onset of ≥1 respiratory symptom. Patients with respiratory symptoms were grouped either as ILI or as ARI based on the presence of fever, malaise, headache and/or myalgia.
Results: Overall, 466 ILI cases and 383 ARI cases occurred. HCP with ILI had an adjusted odds ratio (aOR) of 22.05 [95% confidence interval (CI): 6.23-78.04] to be diagnosed with influenza. HCP with ARI had an aOR of 2.70 (95% CI: 1.88-3.88) to be diagnosed with COVID-19. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ILI for influenza were 96.6%, 49.9%, 18.2%, and 99.2%, respectively. The sensitivity, specificity, PPV, and NPV of ARI for COVID-19 were 51.7%, 73.6%, 84.9%, and 34.8%, respectively. ILI and ARI had an overall correct classification rate of 89.6% and 74.1%, respectively.
Conclusion: Our findings support the use of both ILI and ARI case definitions in the diagnosis of influenza and COVID-19 in HCP.
Competing Interests: Declaration of competing interest Dr Maltezou received an honorarium from Novavax to participate in a symposium. The authors have no conflict of interest to declare.
(Copyright © 2024 Australasian College for Infection Prevention and Control. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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