Diagnosing the Recent Decrease in Utilization of Deceased Donor Kidneys.

Autor:	Wood NL; Hennepin Healthcare Research Institute, Minneapolis, MN., VanDerwerken DN; Department of Mathematics, United States Naval Academy, Annapolis, MD., Massie AB; Department of Surgery, New York University Grossman School of Medicine, New York, NY., Segev DL; Department of Surgery, New York University Grossman School of Medicine, New York, NY., Snyder JJ; Hennepin Healthcare Research Institute, Minneapolis, MN.; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN.; Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN., Gentry SE; Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
Jazyk:	angličtina
Zdroj:	Transplantation [Transplantation] 2024 Aug 28. Date of Electronic Publication: 2024 Aug 28.
DOI:	10.1097/TP.0000000000005178
Abstrakt:	Background: The number of deceased donor kidney transplants has been increasing and is at a record high, yet nonuse of kidneys recovered for transplantation has risen to 25.8% following circular kidney allocation system based on 250-nautical-mile circles implemented on March 15, 2021 (KAS250). Methods: Using Scientific Registry of Transplant Recipients data, we studied all deceased donor kidneys recovered for transplant from March 15, 2019, to January 31, 2023. We calculated the association of multiple factors with kidney nonuse, including increasing recovery of kidneys from nonideal donors, delays in offer acceptance observed under KAS250, and impacts of COVID-19. Results: In the 2 y before KAS250, the nonuse rate was 21.2%. Had this rate continued, 2334 more kidneys would have been transplanted through January 2023. We estimated that about 769 of these nonused kidneys (33%) were associated with offer acceptance delays under KAS250; about 994 of these nonused kidneys (43%) were associated with increased prevalence of nonideal donors: donation after circulatory death donors, older donors, and donors with elevated peak serum creatinine; and about 542 of these nonused kidneys (23%) were associated with an otherwise unexplained gradual upward trend in nonuse of recovered kidneys across the pre-KAS250 and KAS250 eras. The overall impact of COVID-19 on the nonuse rate was not significant. Conclusions: The rise in kidney nonuse rate was significantly associated with both increased recovery of nonideal donors, and with KAS250 allocation complexity and delays. Increasing recovery of kidneys from nonideal donors benefits patients because recovering more kidneys increases the number of kidneys available for transplant. Competing Interests: S.E.G. and D.N.V. were supported by a grant from the Mendez National Institute of Transplantation Foundation. A.B.M., D.L.S., and S.E.G. were supported by grant R01DK132395 from the National Institutes of Health. The other authors declare no conflicts of interest. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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