| Autor: |
Reisman EG; Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia., Caruana NJ; Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia., Bishop DJ; Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia. |
| Jazyk: |
angličtina |
| Zdroj: |
Critical reviews in biochemistry and molecular biology [Crit Rev Biochem Mol Biol] 2024 Jun-Aug; Vol. 59 (3-4), pp. 221-243. Date of Electronic Publication: 2024 Sep 17. |
| DOI: |
10.1080/10409238.2024.2383408 |
| Abstrakt: |
Mitochondria are essential, membrane-enclosed organelles that consist of ∼1100 different proteins, which allow for many diverse functions critical to maintaining metabolism. Highly metabolic tissues, such as skeletal muscle, have a high mitochondrial content that increases with exercise training. The classic western blot technique has revealed training-induced increases in the relatively small number of individual mitochondrial proteins studied (∼5% of the >1100 proteins in MitoCarta), with some of these changes dependent on the training stimulus. Proteomic approaches have identified hundreds of additional mitochondrial proteins that respond to exercise training. There is, however, surprisingly little crossover in the mitochondrial proteins identified in the published human training studies. This suggests that to better understand the link between training-induced changes in mitochondrial proteins and metabolism, future studies need to move beyond maximizing protein detection to adopting methods that will increase the reliability of the changes in protein abundance observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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