Identification of risk loci for postpartum depression in a genome-wide association study.

Autor: Li X; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Regional Alliance for Promoting Liaison Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan., Takahashi N; Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan., Narita A; Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Nakamura Y; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan., Sakurai-Yageta M; Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Murakami K; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Ishikuro M; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Obara T; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Kikuya M; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan.; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan., Ueno F; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Metoki H; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Ohseto H; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Takahashi I; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Nakamura T; Department of Health Record Informatics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Warita N; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan., Shoji T; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan., Yu Z; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan., Ono C; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Regional Alliance for Promoting Liaison Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan., Kobayashi N; Department of Psychiatry, Tohoku University Hospital, Sendai, Japan., Kikuchi S; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Psychiatry, Tohoku University Hospital, Sendai, Japan., Matsuki T; Department of Psychiatry, Tohoku University Hospital, Sendai, Japan., Nagami F; Department of Public Relations and Planning, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Ogishima S; Department of Health Record Informatics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Sugawara J; Department of Community Medical Supports, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan.; Department of gynecology and obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.; Suzuki Memorial Hospital, Iwanumashi, Japan., Hoshiai T; Department of gynecology and obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan., Saito M; Department of gynecology and obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan., Fuse N; Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Kinoshita K; Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Yamamoto M; Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Yaegashi N; Department of Community Medical Supports, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan.; Department of gynecology and obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan., Ozaki N; Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Pathophysiology of Mental Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan., Tamiya G; Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan., Kuriyama S; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan.; Tohoku University International Research Institute of Disaster Sciences, Sendai, Japan., Tomita H; Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Regional Alliance for Promoting Liaison Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan.; Department of Preventive Medicine and Epidemiology, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan.; Department of Psychiatry, Tohoku University Hospital, Sendai, Japan.; Tohoku University International Research Institute of Disaster Sciences, Sendai, Japan.
Jazyk: angličtina
Zdroj: Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2024 Sep 17. Date of Electronic Publication: 2024 Sep 17.
DOI: 10.1111/pcn.13731
Abstrakt: Aim: Genome-wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD-associated loci.
Methods: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders.
Results: A meta-analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P < 5 × 10 -8 ) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over-represented in categories including long-term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling.
Conclusion: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis.
(© 2024 The Author(s). Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.)
Databáze: MEDLINE
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