Modulation of Neurotransmission by Acid-Sensing Ion Channels.
| Autor: | Wu PY; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan., Lien CC; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of physiological investigation [J Physiol Investig] 2024 Sep 01; Vol. 67 (5), pp. 242-248. Date of Electronic Publication: 2024 Sep 17. |
| DOI: | 10.4103/ejpi.EJPI-D-24-00062 |
| Abstrakt: | Abstract: Interstitial pH fluctuations occur normally in the brain and significantly modulate neuronal functions. Acid-sensing ion channels (ASICs), which serve as neuronal acid chemosensors, play important roles in synaptic plasticity, learning, and memory. However, the specific mechanisms by which ASICs influence neurotransmission remain elusive. Here, we report that ASICs modulate transmitter release and axonal excitability at a glutamatergic synapse in the rat and mouse hippocampus. Blocking ASIC1a channels with the tarantula peptide psalmotoxin 1 down-regulates basal transmission and alters short-term plasticity. Notably, the effect of psalmotoxin 1 on ASIC-mediated modulation is age-dependent, occurring only during a limited postnatal period (postnatal weeks 2-6). This finding suggests that protons, through the activation of ASICs, may act as modulators in synapse formation and maturation during early development. (Copyright © 2024 Copyright: © 2024 Journal of Physiological Investigation.) |
| Databáze: | MEDLINE |
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