Birth defects and epidemiological factors in Tunisia.

Autor:	Nasri K; Faculty of Sciences of Bizerte, University of Carthage, 7021 Zarzouna, Bizerte Tunisia.; Embryo-foetopathology department, La Rabta Maternity and Neonatology Center, Tunis El Manar University, 1007 Tunis, Tunisia., Ben Jemaa N; Department of histology-embryology, Faculty of Medicine of Tunis, Tunis El Manar University, 1007 Tunis, Tunisia., Chorfi B; Embryo-foetopathology department, La Rabta Maternity and Neonatology Center, Tunis El Manar University, 1007 Tunis, Tunisia., Sahraoui M; Embryo-foetopathology department, La Rabta Maternity and Neonatology Center, Tunis El Manar University, 1007 Tunis, Tunisia., Masmoudi A; Embryo-foetopathology department, La Rabta Maternity and Neonatology Center, Tunis El Manar University, 1007 Tunis, Tunisia., Siala Gaigi S; Embryo-foetopathology department, La Rabta Maternity and Neonatology Center, Tunis El Manar University, 1007 Tunis, Tunisia.
Jazyk:	angličtina
Zdroj:	La Tunisie medicale [Tunis Med] 2024 Sep 05; Vol. 102 (9), pp. 543-550. Date of Electronic Publication: 2024 Sep 05.
DOI:	10.62438/tunismed.v102i9.5090
Abstrakt:	Aim: To identify the birth defects listed in the embryo-fetopathology department of the maternity and neonatology center of Tunis (Tunisia), and to study the epidemiological factors. Methods: We carried out a retrospective study on 2489 malformed cases including fetuses, stillborns and deceased newborns among 5750 ones autopsied in the embryo-fetopathology department of the maternity and neonatology center of Tunis. Results: The sex ratio of autopsied cases was 1.06. 41% of them weighed less than 500 grams. The gestational age was between 22-28 weeks of amenorrhea in 41.3% of cases. Among the maternal characteristics, we noted an average maternal age of 30.1 years old (with extremes ranging from 16 to 51 years old), and a predominance of O blood group. Parental consanguinity and history of reproductive failure were found respectively in 37.4% and 32.5% of cases. Antenatal diagnosis was established in 62% of cases. It was positive in 59.5% of cases (all types of malformations combined). Among the 2489 malformed cases, 4568 birth defects were identified. Neurological anomalies were the most common (26.01%) followed by nephro-urological anomalies (13.16%) and cardiovascular anomalies (11.47%). During the study period, 164 cases of polymalformative syndromes were counted and 217 cases of chromosomal aberrations were classified. Conclusion: This study allowed us to assess the frequency of birth defects, categorize them based on their type and determine the different epidemiological factors during a long period of nine years, even though our nation does not have a national register of birth defects. In Tunisia, it is important to carry out a national multicenter study in order to set a national register representing the real statistics of these anomalies.
Databáze:	MEDLINE
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