Anoikis in cell fate, physiopathology, and therapeutic interventions.

Autor: Mei J; Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha Hunan China.; Institute of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Central South University Changsha Hunan China.; Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of Education Changsha Hunan China.; National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan China.; Oujiang Laboratory Key Laboratory of Alzheimer's Disease of Zhejiang Province Institute of Aging Wenzhou Medical University Wenzhou Zhejiang China., Jiang XY; Oujiang Laboratory Key Laboratory of Alzheimer's Disease of Zhejiang Province Institute of Aging Wenzhou Medical University Wenzhou Zhejiang China., Tian HX; Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha Hunan China.; Institute of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Central South University Changsha Hunan China.; Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of Education Changsha Hunan China.; National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan China., Rong DC; Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha Hunan China., Song JN; Oujiang Laboratory Key Laboratory of Alzheimer's Disease of Zhejiang Province Institute of Aging Wenzhou Medical University Wenzhou Zhejiang China.; School of Life Sciences Westlake University Hangzhou Zhejiang China., Wang L; Oujiang Laboratory Key Laboratory of Alzheimer's Disease of Zhejiang Province Institute of Aging Wenzhou Medical University Wenzhou Zhejiang China.; Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital Melbourne Victoria Australia.; Ophthalmology Department of Surgery The University of Melbourne Melbourne Victoria Australia., Chen YS; Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha Hunan China.; Institute of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Central South University Changsha Hunan China.; Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of Education Changsha Hunan China.; National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan China., Wong RCB; Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital Melbourne Victoria Australia.; Ophthalmology Department of Surgery The University of Melbourne Melbourne Victoria Australia., Guo CX; Center of Clinical Pharmacology the Third Xiangya Hospital Central South University Changsha Hunan China., Wang LS; Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha Hunan China.; Institute of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Central South University Changsha Hunan China.; Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of Education Changsha Hunan China.; National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan China., Wang LY; Department of Pharmacy Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei Province China., Wang PY; Oujiang Laboratory Key Laboratory of Alzheimer's Disease of Zhejiang Province Institute of Aging Wenzhou Medical University Wenzhou Zhejiang China., Yin JY; Department of Clinical Pharmacology Xiangya Hospital, Central South University Changsha Hunan China.; Institute of Clinical Pharmacology Hunan Key Laboratory of Pharmacogenetics Central South University Changsha Hunan China.; Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of Education Changsha Hunan China.; National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan China.
Jazyk: angličtina
Zdroj: MedComm [MedComm (2020)] 2024 Sep 15; Vol. 5 (10), pp. e718. Date of Electronic Publication: 2024 Sep 15 (Print Publication: 2024).
DOI: 10.1002/mco2.718
Abstrakt: The extracellular matrix (ECM) governs a wide spectrum of cellular fate processes, with a particular emphasis on anoikis, an integrin-dependent form of cell death. Currently, anoikis is defined as an intrinsic apoptosis. In contrast to traditional apoptosis and necroptosis, integrin correlates ECM signaling with intracellular signaling cascades, describing the full process of anoikis. However, anoikis is frequently overlooked in physiological and pathological processes as well as traditional in vitro research models. In this review, we summarized the role of anoikis in physiological and pathological processes, spanning embryonic development, organ development, tissue repair, inflammatory responses, cardiovascular diseases, tumor metastasis, and so on. Similarly, in the realm of stem cell research focused on the functional evolution of cells, anoikis offers a potential solution to various challenges, including in vitro cell culture models, stem cell therapy, cell transplantation, and engineering applications, which are largely based on the regulation of cell fate by anoikis. More importantly, the regulatory mechanisms of anoikis based on molecular processes and ECM signaling will provide new strategies for therapeutic interventions (drug therapy and cell-based therapy) in disease. In summary, this review provides a systematic elaboration of anoikis, thus shedding light on its future research.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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