Intra-ampullary and Periampullary Carcinoma: Clinicopathological Comparison and Survival Outcomes.

Autor:	Hashmi AA; Pathology, Liaquat National Hospital and Medical College, Karachi, PAK., Ali R; Internal Medicine, Liaquat National Hospital and Medical College, Karachi, PAK., Jamal SS; Internal Medicine, Baqai Medical University, Karachi, PAK., Zafar S; Pathology, Liaquat National Hospital and Medical College, Karachi, PAK., Zia S; Pathology, Jinnah Sindh Medical University, Karachi, PAK., Zia F; Pathology, Jinnah Sindh Medical University, Karachi, PAK., Anjali F; Internal Medicine, Sakhi Baba General Hospital, Sukkur, PAK., Kirshan Kumar S; Internal Medicine, Bahria University Medical and Dental College, Karachi, PAK., Irfan M; Statistics, Liaquat National Hospital and Medical College, Karachi, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 16; Vol. 16 (8), pp. e67030. Date of Electronic Publication: 2024 Aug 16 (Print Publication: 2024).
DOI:	10.7759/cureus.67030
Abstrakt:	Introduction The ampulla of Vater is a structure in the duodenal wall in which the biliary and pancreatic ducts open. Malignant epithelial tumors arising at this site are commonly referred to as ampullary adenocarcinomas. In this study, we compared the clinicopathological features of intra-ampullary and periampullary carcinomas, including survival outcomes. Methods This retrospective cross-sectional study was conducted at the Department of Pathology, Liaquat National Hospital. All radiologically suspected cases or biopsy-proven (endoscopic biopsy) cases of intra-ampullary/periampullary carcinoma were included in the study. All patients underwent surgical resection (Whipple's procedure/pancreatoduodenectomy). The classification of intra-ampullary and periampullary carcinomas was performed according to the College of American Pathologists (CAP) guidelines. Results Among the 188 case studies, most (61.7%, n = 116) were males, with a median age of 55 years. Most tumors were of the pancreatobiliary subtype (57.4%, n = 108). Similarly, intra-ampullary carcinoma was more common than periampullary carcinoma (61.7% vs. 38.3%). Intra-ampullary carcinoma showed a higher extent of involvement of adjacent structures, a higher frequency of perineural invasion, and a higher nodal stage than periampullary carcinoma. Similarly, the median disease-specific survival of intra-ampullary carcinoma was significantly lower (46 months) than that of periampullary carcinoma (53.5 months). Conclusion We found a higher incidence of intra-ampullary carcinoma in our study. In addition, intra-ampullary carcinoma had a worse survival rate and was associated with poorer pathological parameters, such as perineural invasion and higher nodal and tumor stages than periampullary carcinoma. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. NA issued approval NA. IRB was not needed as it was a retrospective study (as per institutional policy). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Hashmi et al.)
Databáze:	MEDLINE
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