Dynamic Functional Connectivity Correlates of Trait Mindfulness in Early Adolescence.

Autor:	Treves IN; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts., Marusak HA; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan., Decker A; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Kucyi A; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, Pennsylvania., Hubbard NA; Department of Psychology, University of Nebraska, Lincoln, Nebraska., Bauer CCC; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Psychology, Northeastern University, Boston, Massachusetts., Leonard J; Department of Psychology, Yale University, New Haven, Connecticut., Grotzinger H; Department of Psychological & Brain Sciences, University of California, Santa Barbara, California., Giebler MA; Teachers College, Columbia University, New York, New York., Torres YC; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Imhof A; Department of Psychology, University of Oregon, Eugene, Oregon., Romeo R; Departments of Human Development & Quantitative Methodology and Hearing & Speech Sciences, and Program in Neuroscience & Cognitive Science, University of Maryland College Park, Baltimore, Maryland., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State, Georgia Tech, and Emory, Atlanta, Georgia., Gabrieli JDE; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Jazyk:	angličtina
Zdroj:	Biological psychiatry global open science [Biol Psychiatry Glob Open Sci] 2024 Jul 23; Vol. 4 (6), pp. 100367. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).
DOI:	10.1016/j.bpsgos.2024.100367
Abstrakt:	Background: Trait mindfulness-the tendency to attend to present-moment experiences without judgment-is negatively correlated with adolescent anxiety and depression. Understanding the neural mechanisms that underlie trait mindfulness may inform the neural basis of psychiatric disorders. However, few studies have identified brain connectivity states that are correlated with trait mindfulness in adolescence, and they have not assessed the reliability of such states. Methods: To address this gap in knowledge, we rigorously assessed the reliability of brain states across 2 functional magnetic resonance imaging scans from 106 adolescents ages 12 to 15 (50% female). We performed both static and dynamic functional connectivity analyses and evaluated the test-retest reliability of how much time adolescents spent in each state. For the reliable states, we assessed associations with self-reported trait mindfulness. Results: Higher trait mindfulness correlated with lower anxiety and depression symptoms. Static functional connectivity (intraclass correlation coefficients 0.31-0.53) was unrelated to trait mindfulness. Among the dynamic brains states that we identified, most were unreliable within individuals across scans. However, one state, a hyperconnected state of elevated positive connectivity between networks, showed good reliability (intraclass correlation coefficient = 0.65). We found that the amount of time that adolescents spent in this hyperconnected state positively correlated with trait mindfulness. Conclusions: By applying dynamic functional connectivity analysis on over 100 resting-state functional magnetic resonance imaging scans, we identified a highly reliable brain state that correlated with trait mindfulness. This brain state may reflect a state of mindfulness, or awareness and arousal more generally, which may be more pronounced in people who are higher in trait mindfulness. (© 2024 The Authors.)
Databáze:	MEDLINE
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