Association of serum zinc with mineral stress in chronic kidney disease.

Autor: Sohail A; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria., Obereigner J; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria., Mitter G; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria., Schmid T; AMD GmbH, Linz, Austria., Hofer AS; Department of Medicine III - Nephrology, Hypertension, Transplantation Medicine, Rheumatology, Geriatrics, Ordensklinikum Linz, Linz, Austria., Schuster G; Red Cross Transfusion Service of Upper Austria, Austrian Red Cross, Linz, Austria., Hügl A; Red Cross Transfusion Service of Upper Austria, Austrian Red Cross, Linz, Austria., Dorninger AH; Red Cross Transfusion Service of Upper Austria, Austrian Red Cross, Linz, Austria., Mandl M; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria., Pasch A; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria.; Calciscon AG, Biel, Switzerland., Lackner HK; Division of Physiology and Pathophysiology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Papousek I; Institute of Psychology, Biological Psychology Unit, University of Graz, Graz, Austria., Dieplinger B; Department of Laboratory Medicine, Konventhospital Barmherzige Brueder Linz and Ordensklinikum Linz, Linz, Austria., Suessner S; Red Cross Transfusion Service of Upper Austria, Austrian Red Cross, Linz, Austria., Antlanger M; Department of Internal Medicine 2, Kepler University Hospital and Johannes Kepler University, Linz, Austria., Cejka D; Department of Medicine III - Nephrology, Hypertension, Transplantation Medicine, Rheumatology, Geriatrics, Ordensklinikum Linz, Linz, Austria., Alesutan I; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria., Voelkl J; Institute for Physiology and Pathophysiology, Johannes Kepler University Linz, Linz, Austria.; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Jazyk: angličtina
Zdroj: Clinical kidney journal [Clin Kidney J] 2024 Aug 20; Vol. 17 (9), pp. sfae258. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024).
DOI: 10.1093/ckj/sfae258
Abstrakt: Background: The excessive cardiovascular mortality of patients with chronic kidney disease (CKD) could be linked to mineral stress, the biological consequence of calcium-phosphate nanoparticle exposure. This study investigated whether zinc is associated with mineral stress markers in CKD.
Methods: Z inc and T50 (serum calcification propensity) as well as hydrodynamic radius of secondary calciprotein particles (CPP2) were measured in blood donors and CKD patients with/out dialysis.
Results: Serum zinc concentrations and T50 were reduced, while CPP2 radius was increased in CKD patients. Serum zinc levels positively correlated with T50 and inversely correlated with CPP2 radius. In a hierarchical linear regression model, T50 was associated with age, calcium, phosphate, magnesium and albumin. Addition of zinc significantly improved prediction of the model, confirming an additional contribution of zinc to T50. Similar observations were made for the association of zinc and CPP2 radius, but spiking experiments indicated that zinc may stronger modify T50 than CPP2 radius. Also, urinary zinc excretion was increased in patients with kidney disease and correlated to T50 and CPP2 radius. S erum zinc further correlated with markers of arterial stiffness in blood donors and CKD patients, but these associations did not remain significant in a multivariate linear regression model.
Conclusions: Reduced serum zinc levels in CKD appear directly linked to lower T50 and associated with larger CPP2 radius. Further studies on the associations of zinc and mineral stress as well as putative therapeutic benefits of zinc supplementation are required.
Competing Interests: A.P. is stockholder of Calciscon AG (Biel, Switzerland), which commercializes the mineral stress analysis used in this study.
(© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)
Databáze: MEDLINE
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