Leishmaniasis - Still a diagnostic challenge: An individual participant data systematic review.
| Autor: | Sarfraz A; Senior Research Associate, Department of Pediatrics and Child Health, The Aga Khan University, Karachi, Pakistan., Sarfraz Z; Graduate Medical Researcher, Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan., Liaqat M; Graduate Medical Researcher, Department of Medicine, King Edward Medical University, Lahore, Pakistan., Khan MH; Graduate Medical Researcher, Department of Research, Pakistan Institute of Medical Sciences, Islamabad, Pakistan., Abdul Jabbar HA; Graduate Medical Researcher, Department of Research, Punjab Medical College, Faisalabad, Pakistan., Abdullah M; Graduate Medical Researcher, Department of Research, Fatima Memorial Medical and Dental College, Lahore, Pakistan. |
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| Jazyk: | angličtina |
| Zdroj: | Tropical doctor [Trop Doct] 2024 Oct; Vol. 54 (4), pp. 352-358. Date of Electronic Publication: 2024 Sep 17. |
| DOI: | 10.1177/00494755241273086 |
| Abstrakt: | Leishmania, endemic in nearly half the world's countries, continues to pose significant diagnostic challenges. Our systematic review sought to analyse problems in diagnosis especially in low- to middle-income countries. The average time from symptom onset to diagnosis was 4.5 years. While microscopic detection often failed, polymerase chain reaction showed high sensitivity. Clinical presentations varied significantly, highlighting the complexity of diagnosing leishmaniasis, especially in patients with prolonged disease in non-endemic areas. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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