Splenic marginal zone lymphoma with prolymphocytic transformation and cyclin D1 expression in the absence of CCND1 rearrangement.

Autor: Elbaz Younes I; Department of Pathology, University of Minnesota, Minneapolis, MN, USA., Bunting ST; Department of Pathology, Cleveland Clinic Florida, Westin, FL, USA., Zhang X; Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, 12902 USF Magnolia Dr., Tampa, FL, 33612, USA. xiaohui.zhang@moffitt.org.
Jazyk: angličtina
Zdroj: International journal of hematology [Int J Hematol] 2024 Dec; Vol. 120 (6), pp. 750-754. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1007/s12185-024-03845-6
Abstrakt: Splenic marginal zone lymphoma (SMZL) is one of the most common B-cell lymphomas that affect the spleen. We report a case with splenomegaly and lymphocytosis that showed a clonal B-cell population lacking CD5 and CD10 expression. Notably, the atypical lymphoid cells showed prolymphocytoid morphology and expressed cyclin D1. Fluorescence in-situ hybridization was negative for CCND1/IgH rearrangement. The prolymphocytoid morphology and cyclin D1 expression present a diagnostic pitfall. The clinical presentation, morphology, immunophenotype, and molecular genetic findings are most consistent with a diagnosis of SMZL with prolymphocytic transformation and cyclin D1 expression. Here, we present this case along with a review of the literature, and summarize the clinicopathological characteristics of SMZL with prolymphocytic transformation.
Competing Interests: Declarations. Conflict of interest: The authors declare they have no conflict of interest.
(© 2024. Japanese Society of Hematology.)
Databáze: MEDLINE
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