Neuroanatomical changes observed over the course of a human pregnancy.

Autor: Pritschet L; Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA. laura.pritschet@pennmedicine.upenn.edu., Taylor CM; Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA., Cossio D; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Faskowitz J; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Santander T; Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA., Handwerker DA; Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Grotzinger H; Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA., Layher E; Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA., Chrastil ER; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. chrastil@uci.edu., Jacobs EG; Department of Psychological & Brain Sciences, University of California, Santa Barbara, CA, USA. emily.jacobs@psych.ucsb.edu.; Neuroscience Research Institute, University of California, Santa Barbara, CA, USA. emily.jacobs@psych.ucsb.edu.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Nov; Vol. 27 (11), pp. 2253-2260. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1038/s41593-024-01741-0
Abstrakt: Pregnancy is a period of profound hormonal and physiological changes experienced by millions of women annually, yet the neural changes unfolding in the maternal brain throughout gestation are not well studied in humans. Leveraging precision imaging, we mapped neuroanatomical changes in an individual from preconception through 2 years postpartum. Pronounced decreases in gray matter volume and cortical thickness were evident across the brain, standing in contrast to increases in white matter microstructural integrity, ventricle volume and cerebrospinal fluid, with few regions untouched by the transition to motherhood. This dataset serves as a comprehensive map of the human brain across gestation, providing an open-access resource for the brain imaging community to further explore and understand the maternal brain.
(© 2024. The Author(s).)
Databáze: MEDLINE
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