Human papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer.

Autor: Paradowska E; Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland. eparadowska@cbm.pan.pl., Haręża DA; Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland.; BioMedChem Doctoral School of the University of Lodz and the Institutes of the Polish Academy of Sciences in Lodz, Lodz, Poland., Kania KD; Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland., Jarych D; Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland., Wilczyński M; Department of Surgical, Endoscopic and Oncological Gynecology, Polish Mother's Health Center Research Institute, Lodz, Poland., Malinowski A; Department of Surgical, Endoscopic and Oncological Gynecology, Polish Mother's Health Center Research Institute, Lodz, Poland., Kawecka M; Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232, Lodz, Poland.; Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Nowak M; Department of Gynecology and Obstetrics, Tomaszow Health Center, Tomaszow Mazowiecki, Poland., Wilczyński JR; Department of Gynecology and Obstetrics, Tomaszow Health Center, Tomaszow Mazowiecki, Poland.; Department of Surgical and Oncological Gynecology, Medical University of Lodz, Lodz, Poland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 16; Vol. 14 (1), pp. 21602. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1038/s41598-024-72814-0
Abstrakt: Human papillomaviruses (HPVs) and herpesviruses are detected in patients with epithelial ovarian cancer (EOC). We sought to analyze the prevalence of HPV's 16 and 18, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA in peripheral blood, ovarian, and fallopian tube (FT) tissue samples collected from 97 EOC patients, including 71 cases of high-grade serous ovarian carcinoma (HGSOC), and from 60 women with other tumors or non-neoplastic gynecological diseases. DNA isolates were analyzed by PCR methods, including droplet digital PCR. The results demonstrate that (1) HPV16 DNA has been detected in one-third of the FT and tumor samples from EOCs; (2) the prevalence and quantity of HPV16 DNA were significantly higher in FT samples from HGSOCs, non-HGSOCs, and ovarian metastases than in those from non-neoplastic diseases; (3) CMV and EBV have been detected in approximately one-seventh of EOC samples. The results suggest that HPV16 might be a potential risk factor for EOC development.
(© 2024. The Author(s).)
Databáze: MEDLINE
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