Regional and temporal genotype profiling of Clostridioides difficile in a multi-institutional study in Japan.

Autor: Sagisaka Y; Department of Microbiology and Infection Control, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan., Ishibashi M; Department of Microbiology and Infection Control, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan., Hosokawa D; Department of Microbiology and Infection Control, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan., Nakagawa H; Department of Clinical Laboratory, National Hospital Organization Nagoya Medical Center, 1-1, 4-Chome, Sannomaru, Naka-ku, Nagoya, Aichi, 460-0001, Japan., Yonogi S; Division of Microbiology, Osaka Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka, 537-0025, Japan., Minami K; Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan.; Department of Central Clinical Laboratory, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan., Suzuki Y; Department of Central Clinical Laboratory, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan.; Department of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan., Ogawa T; Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan., Ukimura A; Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan.; Department of Central Clinical Laboratory, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan., Nakano T; Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan.; Department of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan., Komano J; Department of Microbiology and Infection Control, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan. jun.komano@ompu.ac.jp.; Infection Control Center, Osaka Medical and Pharmaceutical University Hospital, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan. jun.komano@ompu.ac.jp.; Department of Microbiology and Infection Control, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-cho, Takatsuki City, Osaka, 569-8686, Japan. jun.komano@ompu.ac.jp.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 16; Vol. 14 (1), pp. 21559. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1038/s41598-024-72252-y
Abstrakt: Clostridioides difficile, a cause of healthcare-associated infections, poses a significant global health threat. This multi-institutional retrospective study focuses on epidemic dynamics, emphasizing minor and toxin-negative clinical isolates through high-resolution genotyping. The genotype of the C. difficile clinical isolates during 2005 to 2022 was gathered from 14 hospitals across Japan (N = 982). The total number of unique genotypes was 294. Some genotypes were identified in every hospital (cross-regional genotypes), while others were unique to a specific hospital or those in close geographic proximity (region-specific genotypes). Notably, a hospital located in a sparsely populated prefecture exhibited the highest prevalence of region-specific genotypes. The isolation rate of cross-regional genotypes positively correlated with the human mobility flow. A 6-month interval analysis at a university hospital from 2019 to 2021 revealed a temporal transition of the genotype dominance. The frequent isolation of identical genotypes over a brief timeframe did not always align with the current criteria for defining nosocomial outbreaks. This study highlights the presence of diverse indigenous C. difficile strains in regional environments. The cross-regional strains may have a higher competency to spread in the human community. The longitudinal analysis underscores the need for further investigation into potential nosocomial spread.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje