Post-thaw CD34+ cell recovery likely degraded under extreme graft platelet concentrations.

Autor: Duarte GC; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand. Gustavo.Duarte@nzblood.co.nz., Ladvanszky L; New Zealand Blood Service, 71 Great South Road, Auckland, New Zealand., Atkinson G; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand.; New Zealand Blood Service, 71 Great South Road, Auckland, New Zealand.; New Zealand Blood Service, 183 Pembroke Street, Hamilton, New Zealand., Burns M; Haematology Department, Christchurch Hospital, 2 Riccarton Avenue, Christchurch, New Zealand., Madola D; New Zealand Blood Service, 71 Great South Road, Auckland, New Zealand., Sadani D; New Zealand Blood Service, 183 Pembroke Street, Hamilton, New Zealand., Yan-Fischer M; New Zealand Blood Service, 71 Great South Road, Auckland, New Zealand., Patel H; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand., Tremblay J; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand.; New Zealand Blood Service, 71 Great South Road, Auckland, New Zealand.; New Zealand Blood Service, 183 Pembroke Street, Hamilton, New Zealand., Butler A; Haematology Department, Christchurch Hospital, 2 Riccarton Avenue, Christchurch, New Zealand., Rathod N; Haematology Department, Waikato Hospital, 183 Pembroke Street, Hamilton, New Zealand., Wei WH; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand. wenhua.wei@manchester.ac.uk.; Centre for Biostatistics, Division of Population Health, Health Services Research and Primary Care, The University of Manchester, Manchester, M13 9PL, UK. wenhua.wei@manchester.ac.uk.
Jazyk: angličtina
Zdroj: Bone marrow transplantation [Bone Marrow Transplant] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.
DOI: 10.1038/s41409-024-02409-w
Abstrakt: Impaired post-thaw CD34 cell (postCD34) viability in autologous haematopoietic stem cell transplant (ASCT) could indicate delayed engraftment where multiple factors might complicate the relationship. Despite of a couple of unconfirmed reports of a negative correlation of platelet concentration with postCD34 viability, how platelets might be involved in the relationship is largely unknown. Therefore, this question was addressed in this retrospective study of 82 ASCT patients with a total of 150 collections of peripheral blood stem cells in New Zealand. A significant negative correction between platelet concentration and postCD34 recovery (r = -0.18, p = 0.028) was observed overall, but upon further analysis only confirmed in the subset with graft platelets 1500-2000 ×10 9 /L. Importantly, the postCD34 recovery was clearly reduced in the subgroups with either the lowest or the highest platelet concentration. The lowest subgroup was enriched with collections from patients with Hodgkin or non-Hodgkin lymphoma, whereas the highest subgroup from patients with multiple myeloma, both with clearly male preponderance. We hypothesized that graft platelet concentrations probably indicated CD34 cell state (e.g. cell cycle and cell adhesion highly related to platelet functions) that sustained when platelet concentrations were within a niche range but went out of kilter otherwise.
(© 2024. The Author(s).)
Databáze: MEDLINE
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