Causal association of sex hormone-binding globulin on gestational hypertension and pre-eclampsia: a two-sample Mendelian randomization study.
| Autor: | Wu Z; The School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China.; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China., Chen J; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China., Huang K; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China., Li Y; Department of Emergency, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China., Chen J; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China., Lin B; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China., Lin C; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China., Pan G; The School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China.; Department of Cardiology, The First Hospital of Putian City, Putian, Fujian, China. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2024 Dec; Vol. 37 (1), pp. 2389979. Date of Electronic Publication: 2024 Sep 16. |
| DOI: | 10.1080/14767058.2024.2389979 |
| Abstrakt: | Objectives: Pre-eclampsia (PE) and gestational hypertension (GH) are two different categories of hypertensive disorders of pregnancy. Given earlier observational research, the relationship between sex hormone-binding globulin (SHBG) and a higher risk of GH/PE is still up for dispute. Hence, the present investigation aimed to examine the possible link between SHBG and the likelihood of GH/PE. Methods: As a first stage, single nucleotide polymorphisms from summary-level genome-wide association studies were tightly screened using quality-control techniques. Afterward, we utilized a two-sample Mendelian randomization (MR) study to examine the causal impact of SHBG on the likelihood of GH/PE. There was no indication of a relationship between blood SHBG level ( n = 214,989) and GH/PE (1864 cases and 461,069 controls) in the initial study. Consensus results were obtained from the replicated analysis, which utilized MR estimates based on serum SHBG level( n = 214,989) for GH (4255 cases and 114,735 controls). Results: The findings did not indicate any proof of a cause-and-effect connection between SHBG and the likelihood of GH/PE (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.999 - 1.00, p = .34). Replicate analysis also revealed similar patterns (OR = 0.92, 95%CI = 0.82-1.05, p = .21). The above findings were demonstrated to have a strong level of robustness. Conclusions: The findings of this research did not offer definitive proof to endorse the idea that SHBG has a direct causal impact on the likelihood of GH/PE, which goes against numerous widely accepted observational studies. To ascertain the potential processes behind the relationships seen in observational studies, more investigation is needed. |
| Databáze: | MEDLINE |
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