Rebalancing the Immune System to Treat Type 1 Diabetes.
| Autor: | Muller YD; Division of Immunology and Allergy, Department of Medicine, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland.; Center for Human Immunology Lausanne, Lausanne University Hospital and University of Lausanne, 1005 Lausanne, Switzerland., Ho P; Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA., Bluestone JA; Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA.; Sonoma Biotherapeutics, South San Francisco, California 94080, USA., Tang Q; Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA Qizhi.Tang@ucsf.edu.; Department of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, California 94143, USA.; Gladstone UCSF Institute of Genome Immunology, San Francisco, California 94158, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16. |
| DOI: | 10.1101/cshperspect.a041599 |
| Abstrakt: | In type 1 diabetes (T1D), the immune system mistakenly attacks the pancreatic islet β cells resulting in the loss of insulin secretion. Insulin-replacement therapy developed more than a century ago provided means to manage the symptoms of diabetes without addressing the root cause of the disease-the faulty immune system. A healthy immune system has built-in mechanisms to limit unwanted, excessive immune activation and prevents damages to self-tissues. These immune self-tolerance mechanisms are often impaired in autoimmune patients including those with T1Ds. Understanding how immune self-tolerance is broken in patients with T1D can inform the design of new curative therapies that correct the immune defects. In this paper, we will summarize the mechanisms of immune tolerance, review their relevance to T1Ds, and discuss novel therapeutic approaches to rebalance the immune system for the treatment of T1Ds. (Copyright © 2024 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| Databáze: | MEDLINE |
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