Cumulative live birth rate of a blastocyst versus cleavage stage embryo transfer policy during in vitro fertilisation in women with a good prognosis: multicentre randomised controlled trial.

Autor:	Cornelisse S; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, Netherlands simone.cornelisse@radboudumc.nl., Fleischer K; Centre for Fertility, Nij Geertgen, Elsendorp, Netherlands., van der Westerlaken L; Reproductive Centre, Leiden University Medical Centre, Leiden, Netherlands., de Bruin JP; Department of Obstetrics and Gynaecology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, Netherlands., Vergouw C; Amsterdam UMC location, Vrije Universiteit Amsterdam, Centre for Reproductive Medicine Amsterdam, Netherlands., Koks C; Department of Obstetrics and Gynaecology, Maxima Medical Centre, Veldhoven, Netherlands., Derhaag J; Centre for Reproductive Medicine, MUMC+, Maastricht, Netherlands., Visser J; Department of Obstetrics and Gynaecology, Amphia Ziekenhuis, Breda, Netherlands., van Echten-Arends J; Centre for Reproductive Medicine, University Medical Centre Groningen, Groningen, Netherlands., Slappendel E; Centre for Fertility, Nij Geertgen, Elsendorp, Netherlands., Arends B; Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, Netherlands., van der Zanden M; Department of Obstetrics and Gynaecology, Haaglanden Medical Centre, The Hague, Netherlands., van Dongen A; Department of Obstetrics and Gynaecology, Hospital Gelderse Vallei, Ede, Netherlands., Brink-van der Vlugt J; Centre for Fertility, Nij Barrahûs, Wolvega, Netherlands., de Hundt M; Department of Obstetrics and Gynaecology, NoordWest Ziekenhuisgroep, Alkmaar, Netherlands., Curfs M; Isala Fertility Centre, Isala Clinics, Zwolle, Netherlands., Verhoeve H; Department of Obstetrics and Gynaecology, OLVG Oost, Amsterdam, Netherlands., Traas-Hofmans M; Department of Obstetrics and Gynaecology, Gelre Ziekenhuizen, Apeldoorn and Zutphen, Netherlands., Wurth Y; IVF Centre, Elisabeth-TweeSteden Ziekenhuis, Tilburg, Netherlands., Manger P; Department of Obstetrics and Gynaecology, Diakonessenhuis, Utrecht, Netherlands., Pieterse Q; Department of Obstetrics and Gynaecology, Haga Ziekenhuis, Den Haag, Netherlands., Braat D; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, Netherlands., van Wely M; Amsterdam UMC, location University of Amsterdam, Centre for Reproductive Medicine, Amsterdam, Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, Netherlands., Ramos L; Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, Netherlands., Mastenbroek S; Amsterdam UMC, location University of Amsterdam, Centre for Reproductive Medicine, Amsterdam, Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	BMJ (Clinical research ed.) [BMJ] 2024 Sep 16; Vol. 386, pp. e080133. Date of Electronic Publication: 2024 Sep 16.
DOI:	10.1136/bmj-2024-080133
Abstrakt:	Objectives: To evaluate whether embryo transfers at blastocyst stage improve the cumulative live birth rate after oocyte retrieval, including both fresh and frozen-thawed transfers, and whether the risk of obstetric and perinatal complications is increased compared with cleavage stage embryo transfers during in vitro fertilisation (IVF) treatment. Design: Multicentre randomised controlled trial. Setting: 21 hospitals and clinics in the Netherlands, 18 August 2018 to 17 December 2021. Participants: 1202 women with at least four embryos available on day 2 after oocyte retrieval were randomly assigned to either blastocyst stage embryo transfer (n=603) or cleavage stage embryo transfer (n=599). Interventions: In the blastocyst group and cleavage group, embryo transfers were performed on day 5 and day 3, respectively, after oocyte retrieval, followed by cryopreservation of surplus embryos. Analysis was on an intention-to-treat basis, with secondary analyses as per protocol. Main Outcome Measures: The primary outcome was the cumulative live birth rate per oocyte retrieval, including results of all frozen-thawed embryo transfers within a year after randomisation. Secondary outcomes included cumulative rates of pregnancy, pregnancy loss, and live birth after fresh embryo transfer, number of embryo transfers needed, number of frozen embryos, and obstetric and perinatal outcomes. Results: The cumulative live birth rate did not differ between the blastocyst group and cleavage group (58.9% (355 of 603) v 58.4% (350 of 599; risk ratio 1.01, 95% confidence interval (CI) 0.84 to 1.22). The blastocyst group showed a higher live birth rate after fresh embryo transfer (1.26, 1.00 to 1.58), lower cumulative pregnancy loss rate (0.68, 0.51 to 0.89), and lower mean number of embryo transfers needed to result in a live birth (1.55 v 1.82; P<0.001). The incidence of moderate preterm birth (32 to <37 weeks) in singletons was higher in the blastocyst group (1.87, 1.05 to 3.34). Conclusion: Blastocyst stage embryo transfers resulted in a similar cumulative live birth rate to cleavage stage embryo transfers in women with at least four embryos available during IVF treatment. Trial Registration: International Clinical Trial Registry Platform NTR7034. Competing Interests: Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: support from Stichting Zorgevaluatie Nederland; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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