Predictors of Mortality in Adults With Calcium Channel Blocker Toxicity Receiving Extra Corporeal Membrane Oxygenation Support: An Extracorporeal Life Support Organization Registry Analysis.

Autor:	Subramanian R; From the Pulmonary and Critical Care Medicine, Parkview Health, Fort Wayne, Indiana., Roebuck A; Parkview Mirro Center for Research and Innovation, Fort Wayne, Indiana.; Department of Biostatistics & Health Data Science, Indiana University School of Medicine Fort Wayne, Fort Wayne, Indiana., Joshi H; From the Pulmonary and Critical Care Medicine, Parkview Health, Fort Wayne, Indiana., Drouin M; Parkview Mirro Center for Research and Innovation, Fort Wayne, Indiana.; Department of Psychology, Purdue University Fort Wayne, Fort Wayne, Indiana.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2024 Sep 03. Date of Electronic Publication: 2024 Sep 03.
DOI:	10.1097/MAT.0000000000002307
Abstrakt:	Calcium channel blocker (CCB) toxicity presents a significant mortality risk, highlighting the need for effective treatment strategies such as extracorporeal membrane oxygenation (ECMO). This study analyzes Extracorporeal Life Support Organization (ELSO) registry data to determine the mortality rate in adults treated with ECMO for CCB toxicity and identifies clinical predictors of mortality. A retrospective analysis of the ELSO registry from January 2016 to April 2023 was conducted, focusing on adults diagnosed with CCB toxicity (ICD-10 T46.1) who received ECMO. Data collected included patient demographics, ECMO details (mode, duration, type), pre-ECMO clinical indicators (pH, lactate levels, cardiac arrest incidence), and in-hospital mortality. The analysis employed descriptive statistics to profile the patient population, with independent t-tests and chi-square tests comparing survivors to nonsurvivors. Logistic regression identified mortality predictors, integrating multiple imputations to remedy missing data, thus ensuring the analysis's integrity. The mortality rate for ECMO-treated CCB toxicity was 40.6%. Severe acidosis and the need for pre-ECMO renal replacement therapy were identified as key predictors of mortality. Further research is needed to determine if early ECMO initiation before a significant pH drop improves outcomes. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu