Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins.

Autor: Blouin MS; Department of Integrative Biology, Oregon State University, Corvallis, Oregon, United States of America., Bollmann SR; Department of Integrative Biology, Oregon State University, Corvallis, Oregon, United States of America., Le Clec'h W; Host Parasite Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Chevalier FD; Host Parasite Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Anderson TJC; Disease Intervention and Prevention Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America., Tennessen JA; Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Sep 16; Vol. 18 (9), pp. e0012474. Date of Electronic Publication: 2024 Sep 16 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0012474
Abstrakt: The trematodes that cause schistosomiasis in humans require aquatic snails as intermediate hosts. Identifying the genes in snails at which allelic variation controls resistance to infection by schistosomes could lead to novel ways to break the cycle of transmission. We therefore mapped genetic variation within the BS90 population of Biomphalaria glabrata snails that controls their resistance to infection by the SmLE population of Schistosoma mansoni. A marker in the PTC2 genomic region strongly associates with variation in resistance. The S-haplotype, which confers increased susceptibility, appears to be almost completely dominant to the R-haplotype, which confers increased resistance. This result suggests a model in which the parasite must match a molecule on the host side to successfully infect. The genomic region surrounding our marker shows high structural and sequence variability between haplotypes. It is also highly enriched for genes that code for single-pass transmembrane (TM1) genes. Several of the TM1 genes present on the S-haplotype lack orthologs on the R-haplotype, which makes them intriguing candidate genes in a model of dominant susceptibility. These results add to a growing body of work that suggests TM1 genes, especially those in this exceptionally diverse genomic region, may play an important role in snail-schistosome compatibility polymorphisms.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Blouin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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