| Autor: |
Castilla-Casadiego DA; Mcketta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States., Loh DH; Mcketta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States., Pineda-Hernandez A; Mcketta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States., Rosales AM; Mcketta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomacromolecules [Biomacromolecules] 2024 Oct 14; Vol. 25 (10), pp. 6319-6337. Date of Electronic Publication: 2024 Sep 16. |
| DOI: |
10.1021/acs.biomac.4c00835 |
| Abstrakt: |
Mesenchymal stromal cells (MSCs) have broad immunomodulatory properties that range from regulation, proliferation, differentiation, and immune cell activation to secreting bioactive molecules that inhibit inflammation and regulate immune response. These properties provide MSCs with high therapeutic potency that has been shown to be relevant to tissue engineering and regenerative medicine. Hence, researchers have explored diverse strategies to control the immunomodulatory potential of stromal cells using polymeric substrates or scaffolds. These substrates alter the immunomodulatory response of MSCs, especially through biophysical cues such as matrix mechanical properties. To leverage these cell-matrix interactions as a strategy for priming MSCs, emerging studies have explored the use of stimuli-responsive substrates to enhance the therapeutic value of stromal cells. This review highlights how stimuli-responsive materials, including chemo-responsive, microenvironment-responsive, magneto-responsive, mechano-responsive, and photo-responsive substrates, have specifically been used to promote the immunomodulatory potential of stromal cells by controlling their secretory activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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