Computational Drug Design Strategies for Fighting the COVID-19 Pandemic.

Autor:	Hakmi M; Medical Biotechnology Laboratory (MedBiotech), Faculty of Medicine and Pharmacy, Bioinova Research Center, Mohammed Vth University, Rabat, Morocco. gml.hakmi@gmail.com.; Mohammed VI Center for Research and Innovation (CM6), Rabat, Morocco. gml.hakmi@gmail.com., Bouricha EM; Medical Biotechnology Laboratory (MedBiotech), Faculty of Medicine and Pharmacy, Bioinova Research Center, Mohammed Vth University, Rabat, Morocco.; Mohammed VI Center for Research and Innovation (CM6), Rabat, Morocco., Soussi A; Department of Informatics, Bioengineering, Robotics and Systems Engineering, University of Genoa, 16145, Genova, Italy., Bzioui IA; Department of Gynecology and Obstetrics, Faculty of Medicine, Abdelmalek Essaâdi University Hospital, Tangier, Morocco., Belyamani L; Mohammed VI Center for Research and Innovation (CM6), Rabat, Morocco.; Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.; Emergency Department, Medical and Pharmacy School, Military Hospital Mohammed V, Mohammed V University, Rabat, Morocco., Ibrahimi A; Medical Biotechnology Laboratory (MedBiotech), Faculty of Medicine and Pharmacy, Bioinova Research Center, Mohammed Vth University, Rabat, Morocco.; Mohammed VI Center for Research and Innovation (CM6), Rabat, Morocco.; Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1457, pp. 199-214.
DOI:	10.1007/978-3-031-61939-7_11
Abstrakt:	The advent of COVID-19 has brought the use of computer tools to the fore in health research. In recent years, computational methods have proven to be highly effective in a variety of areas, including genomic surveillance, host range prediction, drug target identification, and vaccine development. They were also instrumental in identifying new antiviral compounds and repurposing existing therapeutics to treat COVID-19. Using computational approaches, researchers have made significant advances in understanding the molecular mechanisms of COVID-19 and have developed several promising drug candidates and vaccines. This chapter highlights the critical importance of computational drug design strategies in elucidating various aspects of COVID-19 and their contribution to advancing global drug design efforts during the pandemic. Ultimately, the use of computing tools will continue to play an essential role in health research, enabling researchers to develop innovative solutions to combat new and emerging diseases. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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