Diagnostic role of CD64 expression on neutrophils as biomarker for blood stream infection in liver cirrhosis: some preliminary findings.

Autor:	Costa EG; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Venturini S; Department of Infectious Diseases, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Colussi GL; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Pratesi C; Department of Laboratory Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Villalta D; Department of Immunology and Allergology, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Sabena A; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Grembiale A; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Pontoni E; Department of Emergency Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Bramuzzo I; Department of Infectious Diseases, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Barbato G; Department of Emergency Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Balbi M; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of San Vito al Tagliamento, Italy., Doretto P; Department of Laboratory Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Avolio M; Department of Microbiology and Virology, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Basaglia G; Department of Microbiology and Virology, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Crapis M; Department of Infectious Diseases, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Tonizzo M; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy., Fagiuoli S; Gastroenterology Hepatology and Transplantation Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Hospital of Bergamo, Italy., Grazioli S; Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, Hospital of Pordenone, Italy.
Jazyk:	angličtina
Zdroj:	Le infezioni in medicina [Infez Med] 2024 Sep 01; Vol. 32 (3), pp. 363-368. Date of Electronic Publication: 2024 Sep 01 (Print Publication: 2024).
DOI:	10.53854/liim-3203-10
Abstrakt:	Background: The expression of CD64 on neutrophils (nCD64), measured using flow cytometry, has been proposed as a biomarker for bloodstream infections (BSI). However, data regarding its use in the setting of liver cirrhosis are lacking. Methods: We compared nCD64 levels in 15 cirrhotic patients with BSI to those in 19 controls, including outpatients with stable decompensated cirrhosis without infection. Additionally, we compared nCD64 with C-reactive protein (CRP) and procalcitonin (PCT) in infected hospitalized cirrhotic patients. Results: Cirrhotic patients with infection had higher levels of nCD64 compared to controls (6.0 [5.4-7.1] vs. 2.0 [1.5-2.2]; p<0.001). Among infected patients, a correlation between nCD64 (AUC=0.934 [0.875-0.982 95% CI]), CRP (AUC=0.972 [0.942-0.993 95% CI]), and PCT (AUC=0.859 [0.739-0.953 95% CI]) was observed. However, in our sample of cirrhotic individuals, nCD64 values were not significantly different between patients with worse prognosis and those with positive outcomes (p=0.448), and its expression was not influenced by Gram stain. Conclusions: In our cohort, nCD64 appears to be a promising new biomarker for BSI. Additional prospective studies are needed to confirm its role and limitations in conjunction with other biomarkers and rapid microbiology in the diagnostic multidisciplinary pathway for septic cirrhotic patients. Competing Interests: Competing interests: No conflict of interest must be declared for any of the authors.
Databáze:	MEDLINE
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