Evolution of lateralized gustation in nematodes.

Autor:	Mackie M; Department of Biology California State University, Northridge, CA, USA., Le VV; Department of Biology California State University, Northridge, CA, USA., Carstensen HR; Department of Biology California State University, Northridge, CA, USA., Kushnir NR; Department of Biology California State University, Northridge, CA, USA., Castro DL; Department of Biology California State University, Northridge, CA, USA., Dimov IM; Department of Biology California State University, Northridge, CA, USA., Quach KT; Molecular Neurobiology Laboratory Salk Institute for Biological Studies, La Jolla, CA, USA., Cook SJ; Department of Biological Sciences Howard Hughes Medical Institute, Columbia University, New York, NY, USA.; Present address: Neural Coding Department Allen Institute for Brain Science, Seattle, WA, USA., Hobert O; Department of Biological Sciences Howard Hughes Medical Institute, Columbia University, New York, NY, USA., Chalasani SH; Molecular Neurobiology Laboratory Salk Institute for Biological Studies, La Jolla, CA, USA., Hong RL; Department of Biology California State University, Northridge, CA, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 02. Date of Electronic Publication: 2024 Sep 02.
DOI:	10.1101/2024.08.31.610597
Abstrakt:	Animals with small nervous systems have a limited number of sensory neurons that must encode information from a changing environment. This problem is particularly exacerbated in nematodes that populate a wide variety of distinct ecological niches but only have a few sensory neurons available to encode multiple modalities. How does sensory diversity prevail within this neuronal constraint? To identify the genetic basis for patterning different nervous systems, we demonstrate that sensory neurons in the Pristionchus pacificus respond to various salt sensory cues in a manner that is partially distinct from that of the distantly related nematode C. elegans . By visualizing neuronal activity patterns, we show that contrary to previous expectations based on its genome sequence, the salt responses of P. pacificus are encoded in a left/right asymmetric manner in the bilateral ASE neuron pair. Our study illustrates patterns of evolutionary stability and change in the gustatory system of nematodes.
Databáze:	MEDLINE
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