Novel regimens and treatment strategies in neoadjuvant therapy for colorectal cancer: A systematic review.

Autor: Al-Khazraji Y; Department of Medicine, Metropolitan Hospital Center, NY, USA., Muzammil MA; Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan., Javid S; Department of Medicine, CMH Kharian Medical College, Kharian, Pakistan., Tangella AV; Department of Medicine, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India., Gohil NV; Department of Medicine, Medical College Baroda, Vadodara, Gujarat, India., Saifullah H; Department of Medicine, Medical College Baroda, CMH Lahore Medical College, Lahore, Pakistan., Kanagala SG; Department of Medicine, Metropolitan Hospital Center, NY, USA., Fariha F; Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan., Muneer A; Department of Adult Hematology Oncology, Prince Faisal Ca ncer Centre Buraidah, Al qaseem, Saudi Arabia., Ahmed S; Department of Gastroenterology, King Fahad Hospital, Burydah, KSA., Shariq A; Department of Pathology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
Jazyk: angličtina
Zdroj: International journal of health sciences [Int J Health Sci (Qassim)] 2024 Sep-Oct; Vol. 18 (5), pp. 43-58.
Abstrakt: Objective: The objective of this systematic review was to describe novel regimens and treatment strategies in neoadjuvant therapy for colorectal cancer (CRC). The aim was to summarize the current advancements in neoadjuvant chemotherapy (NACT) for CRC, including the use of cytotoxic drugs, targeted treatments, and immunotherapy. The analysis aimed to provide insights into the potential benefits and drawbacks of these novel approaches and highlight the need for further research to optimize NACT use in CRC and improve patient outcomes.
Methods: From October 20, 2023, to December 10, 2023, a comprehensive literature search was conducted across multiple databases, including PubMed, Ovid, Web of Science, the Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, Embase, and Scopus. Studies addressing the use of and treatment strategies for CRC and neoadjuvant therapies were included. Screening was conducted in two steps, initially by title and abstract and then by full-text articles. English-language articles were considered, while preprints, non-English publications, and articles published as grey literature were excluded from the study. A total of 85 studies were selected for further analysis after screening and filtering.
Results: After filtering out duplicates and items that were irrelevant to our research query from the initial database search's 510 results, 397 unique articles were found. Eighty-five studies were chosen for additional analysis after the articles underwent two rounds of screening.
Conclusion: The review concluded that neoadjuvant therapy for CRC has evolved beyond conventional approaches and holds promise for improving patient outcomes. Future prospects for advancing neoadjuvant approaches are promising, with ongoing clinical trials investigating the refinement of strategies, identification of predictive biomarkers, and optimization of patient selection. The adoption of novel regimens, precision medicine, and immunotherapy offers opportunities to redefine treatment paradigms and enhance patient care in CRC.
Competing Interests: None.
(Copyright: © International Journal of Health Sciences.)
Databáze: MEDLINE
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