Mass chemotherapy with niclosamide for the control of Taenia solium : population-based safety profile and treatment effectiveness.

Autor:	Wardle MT; School of Public Health, Oregon Health & Science University and Portland State University, Portland, OR, USA., Allen SE; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Gamboa R; Centro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, Lima and Tumbes, Perú., Vilchez P; Centro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, Lima and Tumbes, Perú., O'Neal SE; School of Public Health, Oregon Health & Science University and Portland State University, Portland, OR, USA.; Centro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, Lima and Tumbes, Perú., Muro C; Centro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, Lima and Tumbes, Perú., Lescano AG; Facultad de Salud Pública y Administración, Universidad Peruana Cayetano Heredia, Lima, Perú., Moyano LM; Centro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, Lima and Tumbes, Perú.; School of Human Medicine, Universidad Nacional de Tumbes, Tumbes, Perú., Gonzalvez GE; Enfermedades Transmisibles y Análisis de Salud, Organización Panamericana de la Salud OPS/OMS, Bogotá, Colombia., González AE; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Perú., Gilman RH; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., García HH; Centro de Salud Global, Tumbes, Universidad Peruana Cayetano Heredia, Lima and Tumbes, Perú.; Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
Jazyk:	angličtina
Zdroj:	Lancet regional health. Americas [Lancet Reg Health Am] 2024 Aug 30; Vol. 38, pp. 100876. Date of Electronic Publication: 2024 Aug 30 (Print Publication: 2024).
DOI:	10.1016/j.lana.2024.100876
Abstrakt:	Background: Mass drug administration (MDA) with niclosamide (NSM) can be used to control taeniasis, the cause of neurocysticercosis. NSM is 84.3% effective against taeniasis and is considered safe as it is not absorbed from the intestinal tract. However, information on its safety and effectiveness during MDA is limited. We evaluated the effectiveness of NSM and reported adverse events (AEs) during a cysticercosis elimination program in Tumbes, Peru. Methods: Three rounds of NSM at 4-month intervals were offered to 77,397 eligible residents. We revisited all participants in their homes 72 h after each round to collect information regarding AEs. We also collected post-treatment stool samples to diagnose taeniasis after the first round, followed by a second sample at 30 days from those infected to evaluate NSM's effectiveness. Findings: During implementation, 68,751 individuals were administered at least one dose of NSM (mean age 29 years, SD 20; 52% male), and 65,551 (95.3%) were visited post-treatment. 988 (1.5%) reported experiencing at least one AE. Almost all AEs (99.2%) were of mild intensity, with no severe AEs recorded. Of 211 participants diagnosed with taeniasis, 188 provided a follow-up stool sample 30-days after treatment and 141 were cured (treatment effectiveness 75.0%). Older age and higher coproantigen levels were significantly associated with treatment failure. Interpretation: MDA with NSM is safe in Taenia solium endemic settings. However, the effectiveness following one dose is lower than expected, which suggests additional treatment may be necessary to enhance the infection control efforts. Funding: The Bill and Melinda Gates Foundation. Competing Interests: RG, PV, CM, and LMM were partially supported by the US National Institutes of Health, the Fogarty International Center (TW001140), AGL was supported by Emerge, the Emerging Diseases Epidemiology Research Training of the US National Institutes of Health, the Fogarty International Center (D43 TW007393), and MTW was supported by the National Center for Advancing Translational Sciences of the US National Institutes of Health under award number (TL1TR00237). HG was supported by a Wellcome Trust International Senior Research Fellowship in Public Health and Tropical Medicine. All authors declare no conflicts of interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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