The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.

Autor:	van Beest EH; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Abdelwahab MAO; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Cazemier JL; Department of Cortical Structure and Function, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Baltira C; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Maes MC; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Peri BD; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Self MW; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands., Willuhn I; Department of Neuromodulation and Behavior, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands.; Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Roelfsema PR; Department of Vision and Cognition, Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, the Netherlands.; Department of Neurosurgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), VU University, Amsterdam, the Netherlands.; Laboratory of Visual Brain Therapy, Sorbonne Université, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Institut de la Vision, Paris, France.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Aug 22; Vol. 27 (9), pp. 110753. Date of Electronic Publication: 2024 Aug 22 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.110753
Abstrakt:	The striatum, the main input nucleus of the basal ganglia, receives topographically organized input from the cortex and gives rise to the direct and indirect output pathways, which have antagonistic effects on basal ganglia output directed to the cortex. We optogenetically stimulated the direct and indirect pathways in a visual and a working memory task in mice that responded by licking. Unilateral direct pathway stimulation increased the probability of lick responses toward the contralateral, non-stimulated side and increased cortical activity globally. In contrast, indirect pathway stimulation increased the probability of responses toward the stimulated side and decreased activity in the stimulated hemisphere. Moreover, direct pathway stimulation enhanced the neural representation of a contralateral visual stimulus during the delay of the working memory task, whereas indirect pathway stimulation had the opposite effect. Our results demonstrate how these two pathways influence perceptual decisions and working memory and modify activity in the dorsal cortex. Competing Interests: The authors declare no competing interests. Affiliations to other research institutions that authors may have at the time of publication are not relevant for the work in this manuscript, nor do they form a conflict of interest. (© 2024 The Author(s).)
Databáze:	MEDLINE
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