Testosterone Therapy for the Treatment of Unexplained Anemia in Men With Hypogonadism.

Autor:	Ali K; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA., Talati J; Internal Medicine, University of Florida College of Medicine, Gainesville, USA., Mikulas C; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA., Quan A; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA., Reddy P; Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 14; Vol. 16 (8), pp. e66887. Date of Electronic Publication: 2024 Aug 14 (Print Publication: 2024).
DOI:	10.7759/cureus.66887
Abstrakt:	Decreased testosterone levels are often under-recognized as a cause of anemia in males with hypogonadism. Men, as a subset, are less likely to seek medical care, especially those who struggle with complex psychiatric and social conditions, where they may lack full autonomy. Increasing testosterone levels leads to erythrocytosis by elevating erythropoietin and soluble transferrin receptor levels and suppressing hepcidin and ferritin levels. While practice guidelines on testosterone therapy for hypogonadism exist, there are no large-scale, randomized clinical trials assessing the use of testosterone replacement therapy in men with hypogonadism to evaluate its effect on anemia. Testosterone replacement therapy is also not wholly benign, and patients may be at increased risk for nonfatal cardiac arrhythmias, venous thromboembolism, and acute kidney injury. We explore two cases of patients with similar prior medical history, both of whom were found to have hypogonadism and anemia that were not otherwise explained. Both patients experienced significant improvement in their anemia following testosterone supplementation. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Ali et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu