Comparison of Different Doses of Pregabalin to Prevent Succinylcholine-Initiated Fasciculations and Myalgia in Patients Under General Anesthesia: A Randomised Controlled Study.

Autor:	Sasidharan M; Anaesthesiology, Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND., Holyachi R; Anaesthesiology, Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND., D PS; Anaesthesiology, Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 16; Vol. 16 (8), pp. e66985. Date of Electronic Publication: 2024 Aug 16 (Print Publication: 2024).
DOI:	10.7759/cureus.66985
Abstrakt:	Background Succinylcholine (SCh) is the most commonly used muscle relaxant during endotracheal intubation, and it is known to cause fasciculations and postoperative myalgia. Pregabalin is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA), which is known to reduce SCh-induced fasciculations and myalgia. Materials and methods This study was conducted on patients who underwent surgery under general anesthesia. A total of 201 patients of both genders were assigned to one of the following groups: Group PL (pregabalin low dose) received cap pregabalin 75 mg, Group PH (pregabalin high dose) received cap pregabalin 150 mg, and Group P (placebo) received saccharine pill 10 mg, administered two hours prior to surgery. Results Both the incidence and severity of fasciculations and myalgia were reduced in patients who received pregabalin compared to the placebo group (PH>PL>P). It was observed that as the severity of fasciculations increased, myalgia also increased. The time of the first analgesic dose was longer in the pregabalin group (PH>PL>P). The attenuation of pressor response and hemodynamic stability was greater in the pregabalin group (Group PH>PL>P). Sedation levels were insignificant among groups. The incidence of adverse effects was also insignificant. Conclusion Preoperative prophylactic administration of pregabalin orally in Group PL and PH reduced the incidence and severity of fasciculations and myalgia. Group PH was found to be more effective than PL. Pressor response attenuation was found to be more effective in Group PH. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Shri B. M. Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura issued approval BLDE (DU)/IEC/781/2022-23. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Sasidharan et al.)
Databáze:	MEDLINE
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